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The effects of sildenafil ciltrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus)- A histological study

Eweka, AO and Eweka, A (2010) The effects of sildenafil ciltrate on the lateral geniculate body of adult Wistar rats (Rattus norvegicus)- A histological study. [Journal (On-line/Unpaginated)]

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Abstract

The histological effect of oral administration of sildenafil citrate (Viagra), commonly used as an aphrodisiac and for the treatment of erectile dysfunction on one of the visual relay centres namely the lateral geniculate body (LGB) of adult Wistar rat was carefully studied. The rats of both sexes (n=24), average weight of 202g were randomly assigned into three treatment (n=18) and control (n=6) groups. The rats in the treatment groups ‘A’, ‘B’ and ‘C’ received respectively, 0.25mg/kg, 0.70mg/kg and 1.43mg/kg body weight of sildenafil citrate base dissolved in distilled water daily for 30 days, through orogastric feeding tube, while that of the control group D, received equal volume of distilled water daily during the period of the experiment. The rats were fed with growers’ mash obtained from Edo Feeds and Flour Mill Ltd, Ewu, Edo State, Nigeria and were given water liberally. The rats were sacrificed on day thirty-one of the experiment. The lateral geniculate body (LGB) was carefully dissected out and quickly fixed in 10% formal saline for histological studies. The histological findings after H&E method indicated that the treated section of the lateral geniculate body (LGB) showed some varying degree of reduced cellular population based on its sparse distribution, degenerative changes, cellular hypertrophy, and intercellular vacuolations appearing in the stroma. Varying dosage and long administration of sildenafil citrate may have some deleterious effects on the neurons of the intracranial visual relay centre and this may probably have some adverse effects on visual sensibilities by its deleterious effects on the cells of the lateral geniculate body (LGB) of adult Wistar rats. It is therefore recommended that further studies aimed at corroborating these observations be carried out.

Item Type:Journal (On-line/Unpaginated)
Keywords:Sildenafil citrate, lateral geniculate body, decreased cellular population, cellular hypertrophy, vacuolations, Wistar rats
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6994
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:13 Sep 2010 03:52
Last Modified:11 Mar 2011 08:57

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. NIH Consensus Conference. Impotence. NIH Consensus Development Panel on Impotence. JAMA 1993;270(1):83–90. doi:10.1001/jama.270.1.83. PMID 8510302.

2. Eardley I, Sethia K (). Erectile Dysfunction: Current Investigation and Management. A textbook, 2nd ed. ISBN 10: 0723433658. Mosby-Elsevier Ltd. 2003. pp. 1-5.

3. Hackett G, Dean J, Kell P, Price D, Ralph D, Speakman M, Wylie K. British Society for Sexual Medicine in: Guidelines on the Management of Erectile Dysfunction. 2007. Available at http://www.bssm.org.uk/downloads/BSSM_ED_Management_Guidelines_2007.pdf

4. Binu T, Bala VM. Botanical therapies in sexual dysfunction. Phytotherapy research 2005;19(6):457-63.

5. Vinik A, Richardson D. Erectile Dysfunction in Diabetes: Pills for Penile Failure J. Clin. Diabetes 1998;16(3):108-130

6. Goldstein I et al. Oral sildenafil in the treatment of erectile dysfunction. N Engl J Med 1998;338:1397–1404.

7. Boolell M et al. Oral sildenafil: an orally active type 5 cyclic GMP specific phosphodiesterase inhibitor for the treatment of penile erectile dysfunction. Int J Impot Res1996;8:47–52.

8. Burnett AL. Nitric oxide in the penis: physiology and pathophysiology. J Urol 1997;157:320–324.

9. McMahon CG, Samali R, Johnson H. Efficacy, safety and patient acceptance of sildenafil citrate as treatment for erectile dysfunction. J Urol. 2000;164:1192–1196.

10. Rosen RC. Psychogenic erectile dysfunction. Classification and management. Urol Clin North Am. 2001;28:269–278.

11. Eardley I. Efficacy and safety of sildenafil citrate in the treatment of men with mild to moderate erectile dysfunction The British Journal of Psychiatry.2001;178:325-330

12. Kerr NM, Danesh-Meyer HV. Phosphodiesterase inhibitors and the eye. Clinical & Experimental Ophthalmology. 2009;37(5):514-523

13. Monatero R, Pipia C, Camarda LKC, Camarda R. Intracerebral haemorrhage associated with sildenafil citrate. J. Neurol. 2001;248(2):141-142.

14. Abdel-Naser MB, Imam A, Wollina U. Sildenafil citrate significantly improves nocturnal penile erections in sildenafil non-responding patients with psychogenic erectile dysfunction. Int. J. Impote. Res. 2004;16:552–556.

15. Cheitlin MD, Hutter AM, Brindis RG, et al. Use of sildenafil (Viagra) in patients with cardiovascular disease. Circulation. 1999;99:168–177.

16. Aviv A, Shelef A, Weizman A. An open-label trial of sildenafil addition in risperidone-treated male schizophrenia patients with erectile dysfunction. Journal of Clinical Psychiatry 2004;65:97–103.

17. Galie N, Ghofrani HA, Torbicki A et al. Sildenafil citrate therapy for pulmonary arterial hypertension. N Engl J Med 2005;17;353:2148-57.

18. Hoeper MM, Welte T, Izbicki G et al. Sildenafil Citrate Therapy for Pulmonary Arterial Hypertension. N Engl J Med. 2006;354:1091-1093.

19. Farooq MU, Naravetla B, Moore PW, Majid A, Gupta R, Kassab MY. Role of Sildenafil in Neurological Disorders. Clinical Neuropharmacology. 2008;31(6):353-362

20. Altman AS, Bayer CS. Time of Origin of neurons of rat superior colliculus in relation to other components of the visual and visiomotor pathways. Exp. Brain Res.1981;42:424-434

21. Moore RY, Card JP. Intergeniculate leaflet: An anatomically and functionally distinct subdivision of the lateral geniculate complex. J. comparative Neurology. 1984;344:403-444

22. VIAGRA Prescribing Information. Pfizer. October 2007. Available at http://www.pfizer.com/files/products/uspi_viagra.pdf Retrieved Aug 21, 2008

23. Viagra and vision. VisionWeb. 29 October 2001 Available at http://www.visionweb.com/content/consumers/dev_consumerarticles.jsp?RID=85.

24. FDA Updates Labeling for Viagra, Cialis and Levitra for Rare Post-Marketing Reports of Eye Problems. United States Food and Drug Administration. 8 July 2005. Available at http://www.fda.gov/bbs/topics/NEWS/2005/NEW01201.html

25. Pomeranz HD, Smith KH, Hart WM, Jr, Egan RA. Sildenafil-associated nonarteric anterior ischemic optic neuropathy. Ophthalmology 2002;109:584–587.

26. Wolfe SM. There have been inadequate warnings that erectile dysfunction drugs can cause blindness. Med Gen Med. 2005;7(4):61.

27. Pomeranz HD, Bhavsar AR. Nonarteric ischemic optic neuropathy developing soon after use of sildenafil (Viagra): A report of seven new cases. Journal of Neuro-Ophthalmology 2005;25:9–13.

28. McGwin G Jr, Vaphiades MS, Hall TA, Owsley C.Non-arteritic anterior ischaemic optic neuropathy and the treatment of erectile dysfunction. Br J Ophthalmol.2006;90(2):154-7.

29. Sadovsky R, Brock GB, Gutkin SW, Sorsaburu S. Toward a new 'EPOCH': optimising treatment outcomes with phosphodiesterase type 5 inhibitors for erectile dysfunction. Int J Clin Pract. 2009;63(8):1214-30.

30. Drury RAB, Wallington EA, Cameron R. Carleton’s Histological Techniques: 4th ed., Oxford University Press NY. U.S.A. 1967 279-280.

31. Wyllie AH. Glucocorticoid-induced thymocyte apoptosis in associated and endogenous endonuclease activation. Nature. 1980;284:555-556.

32. Farber JL Chein KR, Mittnacht S. The pathogenesis of Irreversible cell injury in ischemia. American Journal of Pathology. 1981;102:271-281.

33. Waters CM. Glutamate induced apoptosis of striated cells in rodent model for Parkinsonism. Neuroscience 1994;63:1-5

34. Martins LJ, Al-Abdulla NA, Kirsh JR, Sieber FE, Portera-Cailliau C. Neurodegeneration in excitotoxicity, global cerebral ischaemia and target deprivation: A perspective on the contributions of apoptosis and necrosis. Brain Res. Bull. 1998;46(4):281-309.

35. Cunningham AV, Smith KH. Anterior ischemic optic neuropathy associated with Viagra. Journal of Neuro-Ophthalmology 2001;21:22–25.

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