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Physiological antioxidant system and oxidative stress in stomach cancer patients with normal renal and hepatic function

Reddy, EP and Reddy, VS and Chandra Mouli, K and Rao, PVLNS (2010) Physiological antioxidant system and oxidative stress in stomach cancer patients with normal renal and hepatic function. [Journal (On-line/Unpaginated)]

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Abstract

Role of free radicals has been proposed in the pathogenesis of many diseases. Gastric cancer is a common disease worldwide, and leading cause of cancer death in India. Severe oxidative stress produces reactive oxygen species (ROS) and induces uncontrolled lipid peroxidation. Albumin, uric acid (UA) and Bilirubin are important physiological antioxidants. We aimed to evaluate and assess the role of oxidative stress (OS) and physiological antioxidant system in stomach cancer patients. Lipid peroxidation measured as plasma Thio Barbituric Acid Reactive substances (TBARS), was found to be elevated significantly (p=0.001) in stomach cancer compared to controls along with a decrease in plasma physiological antioxidant system. The documented results were due to increased lipid peroxidation and involvement of physiological antioxidants in scavenging free radicals but not because of impaired hepatic and renal functions.

Item Type:Journal (On-line/Unpaginated)
Keywords:Oxidative stress, Lipid peroxidation, Antioxidants, Stomach cancer
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6979
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:13 Sep 2010 04:54
Last Modified:11 Mar 2011 08:57

References in Article

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1. Ray G, Batra S, Shukla NK, et al. Lipid peroxidation free radical production and antioxidant status in breast cancer. Breast Cancer Res Treat. 2000;59:163-70.

2. Parkin DM, Pisani P, Ferlay J. Global cancer statistics. CA Cancer J Clin. 1999;49:33-64.

3. Liu TS, Wang Y, Chen SY, et al. An updated metaanalysis of adjuvant chemotherapy after curative resection for gastric cancer. EJSO. 2008;34:1208-16.

4. Ko WF, Helzlsouer KJ, Comstock GW. Serum albumin, bilirubin, and uric acid and the anatomic site-specific incidence of colon cancer. J Natl Cancer Inst.1994;86:1874–1875.

5. Roche M, Rondeau P, Singh NR et al. The antioxidant properties of serum albumin. FEBS Letters. 2008;582:1783–1787.

6. Sangeetha P, Das UN, Koratkar R et al. Increase in free radical generation and lipid peroxidation following chemotherapy in patients with cancer. Free Radic Biol Med.1990;8:15-19.

7. Ames BN, Cathcart R, Schwiers E et al. Uric acid provides an antioxidant defense in humans against oxidant- and radical-caused aging and cancer: a hypothesis.Proc Nati Acad Sci. 1981;78:6858-62.

8. Bakan E, Taysi S, Polat MF et al. Nitirc oxide levels and lipid peroxidation in plasma of patients with gastric cancer. Japanese J of Clin Oncology. 2002;32:162-6.

9. Khanzode SS, Khanzode SD, Dakhale GN. Serum and plasma concentration of oxidant and antioxidants in patients of Helicobacter pylori gastritis and its correlation with gastric cancer. Cancer Lett. 2003;195(1):27-31.

10. Akbulut H, Akbulut KG, Icli F et al. Daily variations of plasma malondialdehyde levels in patients with early breast cancer. A Cancer Detect Prev. 2003;27(2):122-6.

11. Gonenc A, Ozkan Y, Torun M, et al. Plasma malondialdehyde levels in breast and lung cancer patients. J Clin Phram Ther. 2001;26(2):141-4.

12. Pasupathi P, Chinnaswamy P, Saravanan G, et al. Effect of chronic smoking on lipid peroxidation and antioxidant status in gastric carcinoma patients. Bangladesh Med Res Counc Bull. 2009;35:1-6.

13. Bourdon E, Blache D. The importance of proteins in defense against oxidation. Antioxid Redox Signal. 2001;3:293–311.

14. Cha MK, Kim IH. Glutathione-linked thiol peroxidase activity of human serum albumin: a possible antioxidant role of serum albumin in blood plasma. Biochem Biophys Res Commun. 1996;222:619–25.

15. Bar-Or D, Rael LT, Lau EP et al. An analog of the human albumin N-terminus (Asp-Ala- His-Lys) prevents formation of copper-induced reactive oxygen species.Biochem Biophys Res Commun. 2001;284:856–862.

16. Pacifici RE, Davies KJA. Protein, lipid and DNA repair systems in oxidative stress: the free-radical theory of aging revisited. Gerontology. 1991;37:166–180.

17. Koc M, Taysi S, Sezen O et al. Levels of some acute phase protein in serum of patients with cancer during radiotherapy. Biol Pharm Bull. 2003;26(10):1494-7.

18. Peden DB, Hohman R, Brown ME et al. Uric acid is a major antioxidant in human nasal airway secretions. Proc Natl Acad Sci. 1990;87:7638–42.

19. Mazza A, Pessina AC, Pavei A et al. Predictors of stroke mortality in elderly people from the general population. The cardiovascular study in elderly. Eur J Epidemiol.2001;17:1097–1104.

20. Petersson B, Trell E, Henningsen NC, et al. Risk factors for premature death in middle aged man. BMJ. 1984;288:1264–68.

21. Levine W, Dyer AR, Shekelle RB et al. Serum uric acid and 11.5-year mortality of middle-aged women: findings of the Chicago Heart Association Detection Project in Industry. J Clin Epidemiol. 1989;42:257–267.

22. Bozkir A, Simsek B, Gungor A, et al. Ascorbic acid and uric acid levels in lung cancer patients. J Clin Pharm Ther. 1999;24:43–47.

23. Mitnick PD, Beck LH. Hypouricemia and malignant neoplasms. Arch Intern Med. 1979;139:1186–87.

24. Passmore R, Eastwood MA, Davidson, et al, editors. Human Nutrition and Dietetics. 8th ed. New York: Churchill Livingston; 1986.

25. Stocker R, Glazer AN, Ames BN. Antioxidant activity of albumin-bound bilirubin. Proc Natl Acad Sci. 1987;84:5918-22.

26. Jacobsen C. Lysine residue 240 of human serum albumin is involved in high-affinity binding of bilirubin. Biochem J. 1978;171:453–9.

27. Neuzil J, Stocker R. Bilirubin attenuates radicalmediated damage to serum albumin. FEBS Lett. 1993;331:281–4.

28. Wei M, Schwertner HA, Gibbons LW et al. Low fasting serum bilirubin as a predictor of cancer mortality in men. Hepatology. 2000;32:427A

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