Cogprints

Impact of Maternal Helicobacter pylori Infection on Trace Elements (Copper, Iron and Zinc) and Pregnancy Outcomes

Ugwuja, EI and Akubugwo, EI (2010) Impact of Maternal Helicobacter pylori Infection on Trace Elements (Copper, Iron and Zinc) and Pregnancy Outcomes. [Journal (On-line/Unpaginated)]

Full text available as:

[img]
Preview
PDF - Published Version
Available under License Creative Commons Attribution No Derivatives.

164Kb

Abstract

Background: H. pylori infection has been suggested to interfere with micronutrient metabolism and influence pregnancy outcomes. Objectives: This study therefore seeks to document the prevalence of H. pylori seroposivity among pregnant women and to determine its impact on some trace element status and pregnancy outcomes. Materials and methods: Three hundred and forty nine consenting pregnant women aged 15-40 years (mean; 27. 04 ± 4. 75 years) and gestational age ≤ 25 weeks (mean 21.77 ± 3.14 wks) attending antenatal clinic at Federal Medical Centre, Abakaliki, between July 2007 and September 2008 participated in the study. H. Pylori antibody (IgG) was determined by a new generation ELISA method. Plasma copper, iron and zinc were analysed using flame atomic absorption spectrophotometer (Bulk Scientific AVG 210 Model) while haemoglobin and albumin were analysed using standard haematological and biochemical techniques. Both maternal sociodemographic and anthropometric parameters were recorded at recruitment. The women were followed-up till delivery after which neonatal anthropometrics and other birth outcomes were recorded. Results: H. pylori seroprevalence of 24.1% (84/349) was recorded with higher prevalence in multiparous and older women. H. pylori infected women had significantly higher BMI (29.00 ± 3.89 vs. 26.86 ± 4.10, p = 0.020) and lower (p > 0.05) plasma levels of Cu, Fe, Zn, albumin, and haemoglobin when compared to non-infected women. Also H. pylori infected women had significantly (p < 0.05) higher rates of convulsion and concomitant illnesses than their non-infected counterparts, although there was no difference in the two groups for other pregnancy outcomes. Conclusion: H. pylori infection during pregnancy seems to interfere with trace element metabolism and contribute significantly to increased maternal morbidity. Prior to confirmation of these findings in a well controlled randomised trial, it is suggested that pregnant women be screened for H. pylori infection to reduce H. pylori associated morbidities during pregnancy.

Item Type:Journal (On-line/Unpaginated)
Keywords:H. pylori, Pregnancy, Trace elements, Copper, Iron, Zinc, Nigeria
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6976
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:13 Sep 2010 04:54
Last Modified:11 Mar 2011 08:57

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Pounder RE, Ng D. The prevalence of Helicobacter pylori infection in different countries. Aliment Pharmacol Ther 1995;9:33-39.

2. Taylor DN, Parsonnet J. Epidemiology and natural history of Helicobacter pylori infection. In: Blaser MJ, Smith PD, Ravin JI, Greeberg HB, Guerrant RL, eds. Infections of the gastrointestinal tract. New York: Raven Press, 1995: 551-63.

3. Thomas JE, Dale A, Harding MW, Coward WA, Cole TJ, Weaver LT. Helicobacter pylori colonization in early life. Paediatr res 1999;45:218-23

4. Parsonnet J, shmuely H, Haggerty T. Faecal and oral shedding of Helicobacter pylori from healthy infected adults. JAMA 1999;282:2240-5

5. Ugwuja EI, Ugwu NC. Helicobacter pylori in uninvestigated dyspepsia in primary health cares in Abakaliki, Nigeria. Online J Health Allied Sci 2007;1: 4

6. Naito Y, Yoshikawa T. Molecular and cellular mechanisms involved in Helicobacter pylori-induced inflammation and oxidative stress. Free Radic Biol Med 2002 33:323-336.

7. Leontiadis GI, Sharma VK, Howden CW. Non-gastrointestinal tract associations of Helicobacter pylori infection. Arch Intern Med 1999;159:925-40.

8. Aslan M, Horoz M, Nazligul Y et al. Insulin resistance in H. pylori infection and its association with oxidative stress. World J gastroenterol 2006;12(42):6865-6868.

9. Gulcelik NE, Kava E, Demirbas B, Culha C, Koc G, Ozkava M, Cakal E, Serter R, Aral Y. Helicobacter pylori prevalence in diabetic patients and its relationship with dyspepsia and autonomic neuropathy. J Endocrinol Invest 2005;28(3):214-7.

10. Chen LH, Luo HS. Effects of H. pylori therapy on erythrocytic and iron parameters in iron deficiency anaemia patients with H. pylori-positive chronic gastritis. World J Gastroenterol 2007;13(40):5380-5383.

11. Mckenna D, Waston P, Dornan J. Helicobacter pylori infection and dyspepsia in pregnancy. Obstet Gynaecol 2003;102(4):845-9.

12. Bromberg SH, Takei K, Garcia SA, Vitor Ada C, Zanoto A, Baracat FF. Helicobacter pylori infection and its correlation with gastrointestinal symptoms and outcome of pregnancy. Rev Assoc Med Bras 2006;52(5):318-22.

13. Eslick GD, Yan P, Xia H-X H, Murray H, Spurrett B, Talley NJ. Foetal intrauterine growth restrictions with Helicobacter pylori infection. Alimen Pharmacol Ther 2002;16(9):1677-1682

14. Yakoob J, Jafri W, Abid S. Helicobacter pylori infection and micronutrient deficiencies. World J Gastroenterol 2003;9(10):2137-2139.

15. Tanriverdi HA, Ustundag Y, Tekin IO, Barut A. Dyspeptic complaints after 20 weeks of gestation are not related to Helicobacter pylori seropositivity. Med Sci Monit 2005;11(9):CR 445-8.

16. Dacie JV, Lewis SM. Practical Haematology. VIII edn. Edinburgh: Churchill Livingstone 1994.

17. World Health Organisation. The prevalence of anaemia in women: a tabulation of available information. W. H. O., Geneva, 1992.

18. Robets WL, McMillin GA, Burtis CA, Bruns DE. In: Reference information for Clinical Laboratory. Tietz textbook of Clinical Chemistry and Molecular Diagnosis (ed) Burtis, C. A., Ashwood, E. R. and Bruns, D. E., 4th edition, Saunders Elsevier, St. Louis Missouri, India 2006. Pp.2251-2302.

19. Reinhold JG. Total protein, albumin and globulin. In M. Reiner (ed). Standard methods in clinical chemistry Vol. Academic Press, New York. 1953. pp: 88.

20. Pronovost AD, Rose SL, Pawlak JW et al. Evaluation of new immunodiagnostic assay for Helicobacter pylori antibody detection: correlation with histopathological and microbiological results. Journal of Clinical Microbiology 1994;32:46-50

21. Woodward M, Morrison C, McColl K. An investigation into factors associated with Helicobacter pylori infection. J Clin Epidemiol 2000;53:175-181.

22. Kivi M, Tindberg Y. Helicobacter pylori occurrence and transmission: a family affair? Scand J Infect Dis 2006;38(6-7):407-17.

23. Ugwuja EI, Ugwu NC. Plasma lipids in H. pylori infected pregnant women. International Journal of Medicine and Medical Sciences 2009;1(5):224-226.

24. Ioannis DK, Ioannis S, Panagiotis D, Vasilios G, Konstantinos D, Aggeliki D Impact of body mass index on fasting blood glucose concentration among Helicobacter pylori carriers. Dig. Dis. 2003;21:262-265.

25. Farag TH, Stoltzfus RJ, Khalfan SS, Tielsch JM. Helicobacter pylori infection is associated with severe anaemia of pregnancy on Pemba Island, Zanzibar. Am j Trop Med Hyg 2007;76(3):541-548.

26. Kearney DJ. Helicobacter pylori infection and iron deficiency anaemia: accumulating evidence in support of a real association. Indian Journal of Gastroenterology (Editorial) 2005;24:147-150.

27. Rafeey M, Zohdy S, Farhang S. H. pylori infection and iron deficiency anaemia in children. Res J Biol Sci 2008;3(6):669-672.

28. Cardenas VM, Mulla ZD, Ortiz M, Graham DY. Iron deficiency and Helicobacter pylori infection in the United States. Am J Epedemiol 2006;163:127-134.

29. Lombard M, Chua E, O’Toole P. Regulation of intestinal non-haem iron absorption. Gut 1997;40:435-9.

30. Charlton RW, Bothwell TH. Iron absorption. Annu Rev Med 1983;34:55-68.

31. Pellicano R, Rizzetto M. Is hepcidin the bridge linking Helicobacter pylori and anaemia of chronic infection? A research proposal Panminerva Medica 2004;46:165-9.

32. Doig P, Austin JW, Trust TJ. The Helicobacter pylori 19.6-kilodalton protein is an iron-containing protein resembling ferritin. J Bacteriol 1993;61:2694-7.

33. Dhaenens L, Szczebara F, Husson MO. Identification, characterization, and immunogenicity of the lactoferin-binding protein from Helocobacter pylori. Infect Immun 1997;65:514-8.

34. Gotz JM, Thio JL, Verspaget HW, Offerhaus GJ, Biemond I, Lamers CB, Veenendaal RA. Treatment of Helicobacter pylori infection favourably affects gastric mucosal superoxide dismutases. Gut 1997;40:591-596.

35. Marreiro DDN, Fisberg M, Cozzolino SMF. Zinc nutritional status in obese children and adolescents. Biol Trace Elem Res 2002;86:107-122.

36. Pearson TC, Guthrie DL, Simpson J, Chinn S, Barosi G, Ferrant A, Lewis SM, Najean Y. Interpretation of measured red cell mass and plasma volume in adults: expert panel on radionuclides of the International Council for Standardization in Haematology. Br J Haematol 1995;89:748-756.

37. Moayyedi p, Soo S, Deeks J et al. on behalf of the Dyspepsia Review Group. Systemic review and economic evaluation of Helicobacter pylori eradication treatment for non-ulcer dyspepsia. BMJ 2000;321:659-664.

38. Blum AL, Tally NJ, O’Morain C et al. Lack of effect of treating Helicobacter pylori infection in patients with non-ulcer dyspepsia. N Engl J Med 1998;339:1875-1881.

Metadata

Repository Staff Only: item control page