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Successful Pregnancy Outcome in a Patient of Chronic Myeloid Leukaemia (CML) Without Any Therapy

Roychowdhury, J and Kundu, AK and Bhattacharya, M (2009) Successful Pregnancy Outcome in a Patient of Chronic Myeloid Leukaemia (CML) Without Any Therapy. [Journal (On-line/Unpaginated)]

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Abstract

The management of cancer during pregnancy may pose difficulty for patients, their families and physicians. The concomitant occurrence of pregnancy and CML is very rare since it is a malignancy which is most commonly detected in elderly. A 30 years old female was diagnosed as a case of CML and prescribed hydroxyurea which she stopped on her own after taking for few months. The patient conceived one month after stopping hydroxyurea. She did not agree to terminate the pregnancy even on repeated requests. Though the total leucocyte count was in the range of 150-200X103/ml, she refused to take any form of therapy till delivery. Antenatal period was uneventful and at term she delivered a male child normally. The mother developed secondary postpartum hemorrhage which was controlled after exploration and removal of retained bits of placenta. Hydroxyurea was started 4 weeks after delivery. Both the mother and the child are doing well till date.

Item Type:Journal (On-line/Unpaginated)
Keywords:Chronic myeloid leukemia, Pregnancy
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6962
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:13 Sep 2010 04:55
Last Modified:11 Mar 2011 08:57

References in Article

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1. Haas JF. Pregnancy in association with a newly diagnosed cancer: a population-based epidemiologic assessment. Int J Cancer 1984;34:229-235.

2. Heartin E, Walkinshaw S, Clark RE. Successful outcome of pregnancy in chronic myeloid leukemia treated with imatinib. Leuk Lymphoma 2004;45:1307–1308.

3. Caligiuri MA, Mayer RJ. Pregnancy and leukemia. Sem Oncol 1989;16:388–396.

4. Asano Y, Okaniwa A. In utero morphological effects of hydroxyurea on the fetal development in Sprague-Dawley rats. Exp Anim 1987;36:143–149.

5. Physicians Desk Reference. 51st Edition. Montvale, NJ. Medical Economics Company, Inc. 1997. p 2308–2311.

6. Earll JM, May RL. Busulfan therapy of myelocytic leukemia during pregnancy. Am J Obstet Gynecol 1965;92:580–581.

7. Jackson N, Shukri A, Ali K. Hydroxyurea treatment for chronic myeloid leukaemia during pregnancy. Br J Haematol 1993;85:203–204

8. Crump M, Wang X-H, Sermer M, Keating A. Successful pregnancy and delivery during alpha-interferon therapy for chronic myeloid leukemia. Am J Hematol1992;40:238–239.

9. Juarez S, Cuadrado Pastor JM, Feliu J, Gonzalez Baron M, Ordonez A, Montero JM. Association of leukemia and pregnancy: clinical and obstetric aspects. Am J Clin Oncol 1988;11:159–65.

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