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Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons

Georgiev, Danko and Taniura, Hideo and Kambe, Yuki and Yoneda, Yukio (2008) Crosstalk Between Brain-Derived Neurotrophic Factor And N-Methyl-D-Aspartate Receptor Signaling In Neurons. [Journal (Paginated)]

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Abstract

Glutamate is the major excitatory neurotransmitter in brain exerting prosurvival effect on neurons via N-methyl-D-aspartate receptor (NMDAR) signaling under physiological conditions. However in pathological circumstances such as ischemia, NMDARs might have proapoptotic excitotoxic activity. In contrast brain-derived neurotrophic factor (BDNF) signaling via TrkB receptors has been largely considered to promote neuronal differentiation, plasticity and survival during normal development, and protect neurons in pathophysiological conditions antagonizing the NMDAR-mediated excitotoxic cell death. In this review we summarize recent evidence for the existent crosstalk and positive feedback loops between the BDNF and NMDAR signaling and point out some of the important specific features of each signaling pathway.

Item Type:Journal (Paginated)
Keywords:NMDA receptor, BDNF, neurotrophins
Subjects:Neuroscience > Neuropharmacology
Neuroscience > Neurophysiology
Neuroscience > Neurochemistry
ID Code:6550
Deposited By:Georgiev, Danko
Deposited On:02 Jul 2009 02:52
Last Modified:11 Mar 2011 08:57

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