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Dose-Dependent Enhancement of Morphine-Induced Analgesia by Ingestion of Amniotic Fluid and Placenta

Kristal, Dr. Mark B. and Abbott, Patricia and Thompson, Alexis C. (1988) Dose-Dependent Enhancement of Morphine-Induced Analgesia by Ingestion of Amniotic Fluid and Placenta. [Journal (Paginated)]

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Abstract

Ingestion of amniotic fluid and placenta by rats has been shown to enhance opioid-mediated analgesia. The present studies were designed to examine the effect of several doses and volumes of placenta and amniotic fluid on tail-flick latency in rats treated with 3 mg/kg morphine. The optimal dose of amniotic fluid was found to be 0.25 ml, although 0.50 and 1.0 ml also produced significant enhancement. Doses of 0.125 and 2 ml of amniotic fluid were ineffective, as was a dose of 0.25 ml diluted to 2 ml with saline. The optimal dose of placenta was found to be 1 placenta, although the resulting enhancement was not significantly greater than that produced by 0.25, 0.50, 2.0 or 4.0 placentas. Doses smaller than 0.25 placenta or larger than 4.0 placentas were ineffective. The most effective doses of amniotic fluid and placenta correspond to the amounts delivered with each pup during parturition.

Item Type:Journal (Paginated)
Keywords:placentophagia, analgesia, opiates, POEF, morphine, maternal behavior, amniotic fluid, rats, opioids, tail-flick latency, parturition, pain
Subjects:Biology > Behavioral Biology
Psychology > Psychobiology
Psychology > Physiological Psychology
Psychology > Comparative Psychology
Biology > Animal Behavior
Neuroscience > Behavioral Neuroscience
Neuroscience > Neurochemistry
ID Code:6220
Deposited By:Kristal, Mark B.
Deposited On:16 Oct 2008 14:49
Last Modified:11 Mar 2011 08:57

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