Cogprints
Login | Create Account

Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy

Sharma, Gaurav Mrinal (2008) Hypoxia Inducible Factor-1α (HIF-1 α) and its Role in Tumour Progression to Malignancy. [Journal (On-line/Unpaginated)]

Full text available as:

[img]
Preview
PDF
144Kb

Abstract

Hypoxia is a condition in which an area of the body or a tissue is deprived of sufficient supply of oxygen. The lack of nutrients in a hypoxic tissue generally causes apoptosis but some cells are able to adapt to this hypoxic environment and resist apoptosis. This adaptation occurs as a result of gene activation. Hypoxia is a characteristic feature of many cancers and is the stimulus for overexpression of HIF-1α - a basic loop-helix PAS protein family subunit of HIF, which allows the cell to adapt and survive in hostile environment. The presence of hypoxia and HIF-1α is correlated with an increased risk of metastasis and techniques that can inhibit hypoxia inducible factor may be instrumental in finding a cure for cancer

Item Type:Journal (On-line/Unpaginated)
Keywords:HIF, HIF-1α, Hypoxia, Malignancy, Cancer, Cancer Therapy
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6202
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:19 Sep 2008 14:59
Last Modified:19 Sep 2008 14:59

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Rockwell, S., Yuan, J., Peretz, S., & Glazer, P. M. (2001). Geneomic instability in cancer. Novartis Foundation Symposium. 240, 133-42.

2. Greijer A E and van der Wall E. The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis. Journal of Clinical Pathology. October 2004;57(10):1009-1014

3. Semenza, G., Shimoda, L. A., & Prabhakar, N. (2005). Regulation of gene expression by HIF-1. Novartis Foundation Symposium. 272, 2-14.

4. Myles R. Joyce, Aoife M. Shannon, Judith Harmey, James Geraghtyb and David Bouchier-Hayes. Oncological implications of hypoxia inducible factor-1α (HIF-1α) expression. Cancer Treatment Reviews. October 2006;32(6):407-416

5. Phua, H. H. (2003). Developing tools for screening therapeutic compounds against the hypoxia-inducible transcription factor-1 (HIF-1) pathway. Unpublished master's thesis. University of Auckland, Auckland, New Zealand.

6. Brahimi-Horn, C., Berra, E., & Pouyssegur, J. (). Hypoxia: the tumor's gateway to progression along the angiogenic pathway. Trends in Cell Biology 2001;11(11):S32-S36.

7. Randy L. Jensen, Brian T. Ragel, Kum Whang and David Gillespie. Inhibition of hypoxia inducible factor-1a (HIF-1a) decreases vascular endothelial growth factor (VEGF) secretion and tumor growth in malignant gliomas. Journal of Neuro-Oncology. 2006;78:233–247

8. Kang Min, Kim Hyon, Kim Hyung, Lee Ji, Kim Dae, Jung, Kyung et al. The effect of age and calorie restriction on HIF-1-responsive genes in aged liver. Biogerontology. January 2005;6(1):27-3

9. Hua Zhong, Angelo M. De Marzo, Erik Laughner, Michael Lim, David A. Hilton, David Zagzag et al. Overexpression of Hypoxia-inducible Factor 1a in Common Human Cancers and Their Metastases. Cancer Research. November 1999;59:5830-5835.

10. Kevin J. Turner, John W. Moore, Adam Jones, Claire F. Taylor, Darren Cuthbert-Heavens, Cheng Han et al. Expression of Hypoxia-inducible Factors in Human Renal Cancer: Relationship to Angiogenesis and to the von Hippel-Lindau Gene Mutation. Cancer Research. May 15, 2002;62:2957–2961

11. Mabjeesh NJ, Amir S. Hypoxia-inducible factor (HIF) in human tumorigenesis. Histology and Histopathology. 2007;22:559-572

12. Gregg L Semenza. Development of novel therapeutic strategies that target HIF-1. Expert Opinion on Therapeutic Targets. April 2006;10(2):267-280

Metadata

Repository Staff Only: item control page

Cogprints is powered by EPrints 3 which is developed by the School of Electronics and Computer Science at the University of Southampton. More information and software credits.