DPOAE in HIV infected adults

Ranjan, Rajesh and Bhat, Jayashree S (2008) DPOAE in HIV infected adults. [Journal (On-line/Unpaginated)]

Full text available as:



HIV infection is associated with impairment of hearing function, at any stage of disease causing complication to the external, middle, inner ear and CNS. Audiological manifestation of HIV is a direct consequence of virus or secondary to the pharmacological treatment or viral complication. Objectives: There is paucity of information pertaining to hearing status in HIV. As the deafness can occur at any stage of HIV with varying degree and people with HIV live longer, there is need to address the hearing problems in these individuals. So this study aimed detecting the outer hair cell functioning by doing DPOAE in normal hearing HIV infected adults. Method: The experimental group comprised of 12 HIV infected (24 ears) within 20 to 40 years. The age matched control group comprised of 15 subjects (30 ears). All the subjects had normal hearing sensitivity. Initially puretone audiometry and immittance was performed for the subject selection. Subsequently DPOAE procedure was done. Results: The DPOAE was abnormal in 50% of the subjects. Conclusion: It can be concluded that the cochlear involvement is a common observation in HIV infected individuals. DPOAE test can be used as a tool for early identification of cochlear pathology in HIV infected.

Item Type:Journal (On-line/Unpaginated)
Keywords:HIV, DPOAE, Outer hair cell function, Central nervous system
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:6090
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:02 Jun 2008 01:33
Last Modified:11 Mar 2011 08:57

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Flower WM, Sooy CD. AIDS: An introduction for speech language pathologist and audiologist. American journal of speech language pathology 1987; 29:25-30

2. Price RW, Brew B, Sidtis J, et al. The brain in AIDS: central nervous system HIV-1 infection and AIDS dementia complex. Science 1988; 239: 586-592

3. Sahakian BJ, Elliot R, Low N, et al. Neurophysiological deficits in tests in executive function in asymptomatic and symptomatic HIV-1 seropositive men. Psychological Medicine 1995; 25:1233-1246

4. Watkins BA, Dorn HH, Kelly WB, et al. Specific tropism of HIV-1 for microglial cells in primary human brain cultures. International weekly Science journal 1990; 249:549-553

5. Fan H, Connor R, Villarreal L. (1991). Introduction: an overview of AIDS. In the biology of AIDS (pp. 1-4). Boston: Jones and Bartlett publishers.

6. Belman AL. Acquired immunodeficiency syndrome and the child’s central nervous system. Pediatric Clinics of North America 1992; 39:691-714

7. Diamond GW, Cohen HJ. Developmental disabilities in children with HIV infection. In AC Crocker, HJ Cohen, & TA Kastner, (1992) (Eds.).HIV infection and developmental disabilities: A resource for services providers. (Pp33-43) Baltimore: Brookes.

8. Straus DJ. Human immunodeficiency virus-associated lymphomas. Medical Clinics of North America 1997; 81:495-510

9. Lalwani AK, Sooy CD. Otology and neurologic manifestations of acquired immunodeficiency syndrome. Otolaryngologic clinic of North America 1992; 25:1183-1197

10. Bankaitis AE, Keith RW. Audiologic changes associated with HIV- infection. ENT Journal 1995; 74:353-359

11. Lipton RB, Krupp L, Horoupian D, et al. Progressive multifocal leukoenecphalopathy of the posteriror fossa in AIDS patients: clinical, radiolographic and evoked potential findings. European Neurology 1988; 28:258-261

12. Rosenhall U, Hakansson C, Lowhagen G, et al. Otoneurological abnormalities in asymptomatic HIV-seropositive patient. Acta Neurologica Scandinavia 1989; 79:140-145

13. Ditchel WJ, Jr. Oral manifestations of human immunodeficiency virus infection. Otolaryngologic Clinics of North America 1992; 25:1211-1226

14. Sooy CD. The impact of AIDS on otolaryngology – head and neck surgery. In N. Myers. (Ed) . Advances in otolaryngology – head and neck surgery 1987; 1: 1–27. Chicago, IL: Year Book Medical Publishers.

15. Brownell WE. Outer hair cell electromotility and otoacoustic emission. Ear Hear 1990; 11:82-92

16. Kemp DT. Cochlear echoes: implications for noise induced hearing loss. In: Hamernic RP, Henderson D, Salvi R,eds. New Perspectives on Noise-Induced Hearing Loss. New York: Raven Press 1982;189-207.

17. Probst R, Lonsbury-Martin B L, Martin GK. A review of otoacoustic emissions. Journal of Acoustic society of America 1991; 89: 2027-2067

18. Kemp DT. Evidence of mechanical nonlinearity and frequency selective wave amplitude in the cochlea. Archeives of Otorhinolaryngology-head and neck surgery 1979; 224:37-46

19. Probst R, Coats A, Martin G, et al. Spontaneous, click and tone burst evoked emissions from normal ears. Hearing and Research journal 1986; 21:261-275

20. Kemp DT. Stimulated acoustic emissions from within the human Auditory system. Journal of Acoustic Society of America 1978; 64:1386-91

21. Probst R, Lonsbury- Martin B, Martin G, et al. Otoacoustic emissions in ears with hearing loss. American Journal of Otolaryngology 1987; 8:73-81

22. 22. Bonfils P, Uziel A. Clinical application of evoked acoustic emissions results in normally hearing and hearing- impaired subjects. Annals of Otorhinolaryngology 1989; 98:26-331

23. Collet L, Gartener M., Moulen M, et al. Evoked oto acoustic emissions and SN hearing loss. Archeives oto laryngol head neck surgery 1989; 115:1060-1062

24. Johnsen N, Parbo J, Elberling C. Evoked otoacoustic emissions from the human ear. scandivian Audiology 1993; 22:87-95.

25. Wilson WR, The relationship of the herpes virus to sudden hearing loss: a prospective clinical study and literature review. Laryngoscope 1986; 96:870-877

26. Shaffer LA, Withnell RH, Dhar S, et al. Sources and mechanisms of DPOAE generation: implications for the prediction of auditory sensitivity. Ear and Hearing journal 2003; 24:367–379

27. McKenzie NF, (Ed). The AIDS reader: Social, political ethical issues. New York: Penguin Books 1991


Repository Staff Only: item control page