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Comparative learning curve analysis: evidence for spared implicit learning in Fragile X mice

Bauchwitz, Dr. Robert (2007) Comparative learning curve analysis: evidence for spared implicit learning in Fragile X mice. [Preprint]

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Abstract

A working memory task for olfactory sequences was employed to test learning set acquisition in mice with a defect in the gene causing Fragile X Syndrome (FXS) in humans. The sequence task protected against reward detection artifact and demonstrated stringency-dependent task acquisition. Despite a previously reported significant deficit among humans with FXS in working memory for sequences of stimuli, the FX mice in this study did not show any statistically detectable differences in learning or memory from wild type. To assess why this might be, a comparable image-based sequence learning set task was used to test humans.The hallmarks of explicit, conscious strategy use by normal human subjects were an abrupt upward inflection in learning curve coincident with inference of the underlying task rule, and a markedly reduced error rate at the plateau region of the learning curve. In contrast, learning curves for the mice showed an extended, gradual improvement in performance with a continually variable error frequency. Based on species learning curve comparisons, it was concluded that mice did not employ explicit, insightful strategies to acquire a sequence rule, but rather used implicit processes. The wild-type performance of the FX mice in this sequence task suggests that implicit learning may be relatively spared in FXS.

Item Type:Preprint
Keywords:Serial learning; Memory, short-term; Fragile X Syndrome; Mental retardation; Models, animal; Psychology, comparative
Subjects:Neuroscience > Behavioral Neuroscience
ID Code:5879
Deposited By:Bauchwitz, Dr. Robert
Deposited On:19 Dec 2007 03:03
Last Modified:19 Dec 2007 03:03

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