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Analgesic Efficacy of Orally Administered Buprenorphine in Rats

Martin, Dr. Lisa B.E. and Thompson, Dr. Alexis C. and Martin, Dr. Thomas and Kristal, Dr. Mark B. (2001) Analgesic Efficacy of Orally Administered Buprenorphine in Rats. [Journal (Paginated)]

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Abstract

The analgesic effect of orally administered buprenorphine was compared with that induced by a standard therapeutic injected dose (0.05 mg/kg of body weight, s.c.) in male Long-Evans rats. Analgesia was assessed by measuring pain threshold, using the hot-water tail-flick assay before and after administration of buprenorphine. The results suggest that a commonly used formula for oral buprenorphine in flavored gelatin, at a dose of 0.5 mg/kg, does not increase pain threshold in rats. Instead, oral buprenorphine doses of 5 and 10 mg/kg were necessary to induce significant increases in pain threshold. However, these doses had to be administered by orogastric infusion because the rats would not voluntarily eat flavored gelatin containing this much buprenorphine. The depth of analgesia induced by these infused doses was comparable to that induced by the clinically effective s.c. treatment (0.05 mg/kg).

Item Type:Journal (Paginated)
Keywords:buprenorphine, analgesia, pain, rat
Subjects:Neuroscience > Behavioral Neuroscience
ID Code:5722
Deposited By:Kristal, Mark B.
Deposited On:29 Sep 2007 00:23
Last Modified:11 Mar 2011 08:56

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