The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils

Candelario-Jalil, Eduardo and Alvarez, Dalia and Castaneda, Juana M. and Al-Dalain, Saied M. and Martinez-Sanchez, Gregorio and Merino, Nelson and Leon, Olga S. (2002) The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. [Journal (Paginated)]

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Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils. The extent of ischemic injury was assessed behaviorally by measuring the increases in locomotor activity and by histopathological evaluation of the extent of CA1 hippocampal pyramidal cell injury 7 days after ischemia. DFU treatment (10 mg/kg, p.o.) significantly reduced hippocampal neuronal damage even if the treatment is delayed until 12 h after ischemia. These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury.

Item Type:Journal (Paginated)
Keywords:cyclooxygenase-2; cerebral ischemia; neuroprotection; hippocampus; gerbil; DFU; prostaglandin E2; stroke; brain
Subjects:Neuroscience > Neurochemistry
ID Code:5645
Deposited By:Candelario-Jalil, Dr Eduardo
Deposited On:20 Aug 2007
Last Modified:11 Mar 2011 08:56

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