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The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils

Candelario-Jalil, Eduardo and Alvarez, Dalia and Castaneda, Juana M. and Al-Dalain, Saied M. and Martinez-Sanchez, Gregorio and Merino, Nelson and Leon, Olga S. (2002) The highly selective cyclooxygenase-2 inhibitor DFU is neuroprotective when given several hours after transient cerebral ischemia in gerbils. [Journal (Paginated)]

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Abstract

Several studies suggest that cyclooxygenase-2 contributes to the delayed progression of ischemic brain damage. In this study we examined whether the highly selective cyclooxygenase-2 inhibitor DFU reduces neuronal damage when administered several hours after 5 min of transient forebrain ischemia in gerbils. The extent of ischemic injury was assessed behaviorally by measuring the increases in locomotor activity and by histopathological evaluation of the extent of CA1 hippocampal pyramidal cell injury 7 days after ischemia. DFU treatment (10 mg/kg, p.o.) significantly reduced hippocampal neuronal damage even if the treatment is delayed until 12 h after ischemia. These results suggest that selective cyclooxygenase-2 inhibitors may be a valuable therapeutic strategy for ischemic brain injury.

Item Type:Journal (Paginated)
Keywords:cyclooxygenase-2; cerebral ischemia; neuroprotection; hippocampus; gerbil; DFU; prostaglandin E2; stroke; brain
Subjects:Neuroscience > Neurochemistry
ID Code:5645
Deposited By:Candelario-Jalil, Dr Eduardo
Deposited On:20 Aug 2007
Last Modified:11 Mar 2011 08:56

References in Article

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[1] A.M. Babcock, D.A. Baker, R. Lovec, Locomotor activity in the ischemic gerbil, Brain Res. 625 (1993) 351-354.

[2] P. Bezzi, G. Carmignoto, L. Pasti, S. Vesce, D. Rossi, B.L. Rizzini, T. Pozzan, A. Volterra, Prostaglandins stimulate calcium-dependent glutamate release in astrocytes, Nature 391 (1998) 281-285.

[3] E. Candelario-Jalil, H.H. Ajamieh, S. Sam, G. Martínez, O.S. León, Nimesulide limits kainate-induced oxidative damage in the rat hippocampus, Eur. J. Pharmacol. 390 (2000) 295-298.

[4] E. Candelario-Jalil, N.H. Mhadu, S.M. Al-Dalain, G. Martínez, O.S. León, Time course of oxidative damage in different brain regions following transient cerebral ischemia in gerbils, Neurosci. Res. 41 (2001) 233-241.

[5] C. Cazevieille, A. Muller, F. Meynier, N. Dutrait, C. Bonne, Protection by prostaglandins from glutamate toxicity in cortical neurons, Neurochem. Int. 24 (1994) 395-398.

[6] S. Govoni, E. Masoero, L. Favalli, A. Rozza, R. Scelsi, S. Viappiani, C. Buccellati, A. Sala, G. Folco, The cyclooxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ischemia in the rat, Neurosci. Lett. 303 (2001) 91-94.

[7] S.J. Hewett, T.F. Uliasz, A.S. Vidwans, J.A. Hewett, Cyclooxygenase-2 contributes to N-methyl-D-aspartate-mediated neuronal cell death in primary cortical cell culture, J. Pharmacol. Exp. Ther. 293 (2000) 417-425.

[8] L. Ho, H. Osaka, P.S. Aisen, G.M. Pasinetti, Induction of cyclooxygenase (COX)-2 but not COX-1 gene expression in apoptotic cell death, J. Neuroimmunol. 89 (1998) 142-149.

[9] C. Iadecola, K. Niwa, S. Nogawa, X. Zhao, M. Nagayama, E. Araki, S. Morham, M.E. Ross, Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurotoxicity in cyclooxygenase-2-deficient mice, Proc. Natl. Acad. Sci. USA 98 (2001) 1294-1299.

[10] K.A. Kelley, L. Ho, D. Winger, J. Freire-Moar, C.B. Borelli, P.S. Aisen, G.M. Pasinetti, Potentiation of excitotoxicity in transgenic mice overexpressing neuronal cyclooxygenase-2, Am. J. Pathol. 155 (1999) 995-1004.

[11] T. Kirino, Delayed neuronal death in the gerbil hippocampus following ischemia, Brain Res. 239 (1982) 57-69.

[12] T. Kirino, Delayed neuronal death, Neuropathology 20 (2000) S95-S97.

[13] J. Koistinaho, S. Koponen, P.H. Chan, Expression of cyclooxygenase-2 mRNA after global ischemia is regulated by AMPA receptors and glucocorticoids, Stroke 30 (1999) 1900-1906.

[14] J. Koistinaho, T. Hökfelt, Altered gene expression in brain ischemia, NeuroReport 8 (1997) i-viii.

[15] S.R. Lee, S.I. Suh, S.P. Kim, Protective effects of the green tea polyphenol (-)-epigallocatechin gallate against hippocampal neuronal damage after transient global ischemia in gerbils, Neurosci. Lett. 287 (2000) 191-194.

[16] L.J. Marnett, S.W. Rowlinson, D.C. Goodwin, A.S. Kalgutkar, C.A. Lanzo, Arachidonic acid oxygenation by COX-1 and COX-2. Mechanisms of catalysis and inhibition, J. Biol. Chem. 274 (1999) 22903-22906.

[17] T. Nakagomi, T. Sasaki, T. Kirino, A. Tamura, M. Noguchi, I. Saito, K. Takakura, Effect of cyclooxygenase and lipoxygenase inhibitors on delayed neuronal death in the gerbil hippocampus, Stroke 20 (1989) 925-929.

[18] M. Nakayama, K. Uchimura, R.L. Zhu, T. Nagayama, M.E. Rose, R.A. Stetler, P.C. Isakson, J. Chen, S.H. Graham, Cyclooxygenase-2 inhibition prevents delayed death of CA1 hippocampal neurons following global ischemia, Proc. Natl. Acad. Sci. USA 95 (1998) 10954-10959.

[19] S. Nogawa, F. Zhang, M.E. Ross, C. Iadecola, Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage, J. Neurosci. 17 (1997) 2746-2755.

[20] W.A. Pulsinelli, J.B. Brierley, F. Plum, Temporal profile of neuronal damage in a model of transient forebrain ischemia, Ann Neurol 11 (1982) 491-498.

[21] D. Riendeau, M.D. Percival, S. Boyce, C. Brideau, S. Charleson, W. Cromlish, D. Ethier, J. Evans, J.P. Falgueyret, A.W. Ford-Hutchinson, R. Gordon, G. Greig, M. Gresser, J. Guay, S. Kargman, S. Léger, J.A. Mancini, G. O´Neill, M. Ouellet, I.W. Rodger, M. Thérien, Z. Wang, J.K. Webb, E. Wong, L. Xu, R.N. Young, R. Zamboni, P. Prasit, C.C. Chan, Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor, Br. J. Pharmacol. 121 (1997) 105-117.

[22] T. Sasaki, T. Nakagomi, T. Kirino, A. Tamura, M. Noguchi, I. Saito, A. Takakura, Indomethacin ameliorates ischemic neuronal damage in the gerbil hippocampal CA1 sector, Stroke 19 (1998) 1399-1403.

[23] H. Wakita, H. Tomimoto, I. Akiguchi, J.X. Lin, K. Miyamoto, N. Oka, A cyclooxygenase-2 inhibitor attenuates white matter damage in chronic cerebral ischemia, NeuroReport 10 (1999) 1461-1465.

[24] B.C. White, L.I. Grossman, B.J. O´Neil, D.J. DeGracia, R.W. Neumar, J.A. Rafols, G.S. Krause, Global brain ischemia and reperfusion, Ann. Emerg. Med. 27 (1996) 588-594.

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