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Human Microsporidial Infections

I CJ, Omalu and D D, Duhlinska and G I, Anyanwu and V A, Pam and P U, Inyama (2006) Human Microsporidial Infections. [Journal (On-line/Unpaginated)]

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Abstract

Microsporidia are eukaryotic, spore forming obligate intracellular parasites, first recognised over 100 years ago. Microsporidia are becoming increasingly recognised as infectious pathogens causing intestinal and extra-intestinal diseases in both immuno-competent and immuno-suppressed patients. They are characterised by the production of resistant spores that vary in size depending on the species; and poses a unique organelle, the polar tubule (polar filament), which is coiled inside the spore as demonstrated by its ultra structure. Other unusual characteristics are the lack of mitochondria and the prokaryotic-like ribosomes, which indicate the primitive nature of the group. Presently there are seven genera, Enterocytozoon, Encephalitozoon, Nosema, Pleistophora, Trachi pleistophora, Brachiola, vittaforma species which have been reported from human hosts as agents of systemic, ocular, intestinal and muscular infections, are described and the diagnosis, treatment, and source of infections discussed.

Item Type:Journal (On-line/Unpaginated)
Keywords:Microsporidia, Enterocytozoon, Encephalitozoon, Nosema, Pleistophora, Diagnosis
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:5321
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:22 Dec 2006
Last Modified:11 Mar 2011 08:56

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Matsubayashi H, Koike T, Mikata I, Takei H, Hagiwara S. A case of Encephlitozoon - like body in man. Archives of Pathology 1959;67:181–187.

2. Weber R, Bryan RT, Schwatts DA, Owen RL. Human Microsporidial infections. Clinical Microbiology Reviews 1994;7:426–461.

3. Omalu ICJ, Duhlinska DD, Anyanwu GI, Yako AB. Prevalence of Microsporidiosis in Immunocounprised patients in Kano State. Proceedings of the 4th National Conference of the League of Researchers in Nigeria in Law Auditorium of University of Jos. 28th October, 2002.

4. Nageli KW. Uber die neue krankheit der seidenraupe und verwante organismen. Bot Zeit 1857;15: 760 – 761.

5. Balbiani M. Sur les microsporidies ou psorospermies des articules. C R Academy of Science 1882;95: 1168–1171.

6. Sprague V. Annotated lists of species of microsporidia. In: Bulla LA, Cheng TC, eds. Comparative pathobiology, vol. 2: Systematics of the microsporidia. New York: Plenum press. 1976;331-334

7. Kudo R. A biologic and taxonomic study of the microsporidia. III Biological Monograph 1924;9:1–268

8. Canning EU, Hollister WS. Human infections with Microsporidia. Reviews in Medical Microbiology 1992;3:35-42,

9. CDC. Microsporidiosis Parasite and Health. 2004;1–3pp.

10. Joseph J, Vemuganti GK, Sharma S. Microsporidia: Emerging ocular Pathogens. Indian Journal of Medical Microbiology 2005;23:80–91.

11. Vossbrinck CR, Maddox JV, Friedman S, Debrunner-Vossbrinck BA, Woese CR. Ribosomal RNA sequence suggests Microsporidia are extremely ancient eukryotes. Nature 1987;326:411-414.

12. Weiss L, Vossbrinck C. Molecular biology, molecular phylogeny, and molecular diagnostic approaches to the microsporidia. In Wittner M, Weiss L, editors, The Microsporidia and Microsporidiosis, Washington DC: American Society of Microbiology 1999;pp. 120–271

13. Schwartz DA, Bryan RT, Weber R, Visvesvara GS. Microsporidiosis in HIV positive patients: Current methods for diagnosis using biopsy, Cytologic, techniques. Folia parasitologica 1994;41:101-109.

14. Lom J. Introductory remarks on Microsporidia in the AIDS era. Folia Parasitologica 1993;40:255-256.

15. Omalu ICJ, Duhlinska DD, Anyanwu GI, Yako AB, Inyama PU. Detection of Encephalitozoon species in urine and sputum samples of immunocompromised patients in Kano State. A paper presented at the 2nd Annual Conference of the Zoological Society of Nigeria held at the Institute of Development Reseach at Ahmadu Bello University Zaria on 8th – 9th of November, 2004.

16. Ashton N, Wirasinha PA. Encephlitozoonosis (nematosis) of the cornea. British Journal of Ophthamology 1973;57:669–674

17. Ashton N, Cook C, Clegg F. Encephlitozoonosis (nematosis) causing bilateral cataract in a rabbit. British Journal of Ophthamology 1976;60:618 – 631.

18. Pinnolis M, Egbert PR, Font RL, Winter FC. Nosematosis of the Cornea. Case report, including electron Microscopic studies. Achives of Ophthamology 1981;99:1044-1047.

19. Shadduck JA, Meccoli RA, Davis R, Font R. Isolation of a Microsporidian from a human patient. Journal of Infectious Diseases 1990;162:773-776.

20. Ledford DK, Overman MD, Gonzalvo A, Cali A, Mester SW, Lockey RF. Microsporidiosis myositis in a patient with acquired immunodeficiency sydrome. Annals of internal Medicine 1985;102:628-630.

21. Margileth AM, Strano AJ, Chandra R, Neafie R, Blum M, McCully RM. Disseminated nosematosis in an immunological compromised infant. Archives of Pathology 1973;95:145–150.

22. Bergquist NR, Stintzing G, Smedman L, Wallert T. Diagnosis of encephalitozoonosis in Man by Serological tests. British Medical Journal 1984;288:902-903

23. Terada S, Reddy KR, Jeffers LJ, Cali A, Schiff ER. Microsporidian hepatitis in the Acquired Immunodefiency Syndrome. Annals of internal Medicine 1987;107:61-62.

24. Canning EU, Lom J. The Microsporidia of Vertebrates. London. Academic Press, 2nd Edition. 1986;289p.

25. Lowder CY, Meisler DM, McMahon JT, Longworth DL, Rutherford I. Microsporidia infection of the cornea in a man seropositive for human immunodeficiency virus. American Journal of Ophthamology 1990;109: 242-244.

26. Friedberg DN, Stenson SM, Orenstein JM, Tierno PM, Charles NC. Microsporidial keratoconjunctivitis in acquired immunodeficiency sydrome. Ophthamology 1990;108:504-508.

27. Orenstein JM, Chiang J, Steinberg W, Smith PD, Rotterdam H, Kotler DP. Intestinal Microsporidiosis as a cause of diarrhoea in human immunodeficiency virus infected patients: a report of 20 cases. Human Pathology 1990;21(5):475-481.

28. Didier ES, Didier PJ, Friedberg DN et al. Isolation and characterization of new human microsporidian, Encephalitozoon hellem (n.sp) from three AIDS patients with keratoconjunctivitis. Journal of Infectious Diseases 1991;163:617-621.

29. Metcalfe, T, Doran R, Rowland P, Curry A, Lacey CJN. (). Microsporidial Keratoconjunctivitis in a British patient with AIDS. British Journal of Ophthamology 1992;76:177-178.

30. Lacey CJ, Clark A, Frazer P, Metcalfe T, Bonsor G, Curry A. Chronic Microsporidian infection in the Nasal Mucosae, Sinuses, and conjunctivae in HIV disease. Genitourinary Medicine 1992;68:179-181.

31. Desportes L, LeCharpentier Y, Galian A, Bernard F, Cochand-Priollet B, Larvergae A, Ravisse P, Modigliani R. Occurrence of a new Microsporidian, Enterocytozoon bieneusi n.g., n.sp., in the enterocytes of a human patient with AIDS. Journal of Protozoology 1985;32:250-254.

32. Curry A, Canning EU. Human Microspodiosis. Journal of Infection 1993;27:229-236.

33. Van-Gool T, Hollister WS, Eeftinck-Schattenkerk J et al. Diagnosis of Enterocytozoon bieneusi Microsporidiosis in AIDS patients by recovery of spores from faces. The Lancet 1990;336:697-698.

34. Blanshard C, Ellis DS, Tovey DG, Dowell S, Gazzard BG. Treatment of intestinal Microsporidiosis with albendazole in patients with AIDS. AIDS 1992;6:311–313.

35. Hollister WS, Canning EU. An Enzyme Linked Immunosorbent Assay (ELISA) for detection of antibodies to Encephalitozoon cuniculi and its use in determination of infections in man. Parasitology 1987;94:209-219.

36. Hollister WS, Canning EU, Wilcox A. Evidence for Widespread Occurrence of antibodies to Encephalitozoon cuniculi (Microspora) in man provided by ELISA and other serological tests. Parasitology 1991;102:33-43.

37. Muller A, Stellermann K, Hartmann P et al. A Powerful DNA extraction method and PCR for detection of Microsporidia in clinical stool specimens. Journal of Infectious Diseases 1999;44:22-25.

38. Orenstein JM, Dieterich DT, Kotler DP. Albendazole as a treatment for disseminated microsporidiosis due to Encephalitozoon intestinalis in AIDS patients. AIDS 1993;6:311–313.

39. Katznelson H, Jamieson CA. Control of nosema disease of honeybees with fumagilin. Sciences 1952;115 70–71.

40. Hsiao TH, Hsiao C. Benomyl: a novel drug for controlling a microsporidian disease of alfafa weevil. Journal of Invertebrate pathology 1973;22:303–304.

41. Overstreet RM. Buquinolate as a preventive drug to control microporidiosis in the blue crab. Journal of Invertebrate Pathology 1975;25:213–216.

42. Mehlhorn H, Schmahl G, Haberkorn A. Toltrazuril effective against a broad spetrum of Protozoan parasities. Parasitological Research 1988;75:64-66.

43. Lin TP, Murick GR. Deformities in the spores of Nosema apis as induced by itraconazole. Parasitological Research 1989;75:498-502.

44. Cox JC, Hamilton RC, Attwood HD. An investigation of the route and progression of Encephalitozoon cuniculi infection in adult rabbits. Journal of Protozoology 1979;26:260–265.

45. Didier ES, Varner PW, Didier PJ et al. Experimental Microsporidiosis in Immunocompetent and Immunodeficient Mice and Monkeys. Folia Parasitologica 1994;41:1-11

46. Visvesvara GS, Leitch GJ, Da silva AG, Croppo GP, Moura H, Wallace S. Polyclonal and Monoclonal antibody and PCR-amplified small sub-unit rRNA identification of microsporidia; Encephliyozoon hellem, isolated from an AIDS patient with disseminated infection. Journal of Clinical Mirobiology 1994;32:2760–2768.

47. Visvesvara GS, Da silva AG, Croppo GP, Pieniazek NJ, Lietch GJ, Ferguson D. In vitro culture and serologic and molecular identification of Septata intestinalis isolated from urine of a patient with AIDS. Journal of Clinical Mirobiology 1995;33:930–936.

48. Koudela B, Vitovec J, Kucerova Z, Ditrich O, Travnicek J. The severe combined immunodeficiency mouse as a Model for Encephalitozoon cuniculi Microsporidiosis. Folia Parasitologica 1993;40:279-286.

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