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Subclinical microcrania, subclinical macrocrarnia, and fifth-month fetal markers (of growth retardation or edema) in schizophrenia: a co-twin control study of discordant monozygotic twins.

Bracha, HS and Gil, P and Lange, B and Gilder, J and Torrey, EF and Gottesman, II and McCray, DS (1995) Subclinical microcrania, subclinical macrocrarnia, and fifth-month fetal markers (of growth retardation or edema) in schizophrenia: a co-twin control study of discordant monozygotic twins. [Journal (Paginated)]

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Abstract

Summary: We tested the hypothesis that gestational injuries in some patients with schozophrenia would leave their mark as a subtle reduction in head circumference (subclinical microcrania). Conclusions: The head circumferences of all subjects were in the normal range. Decreased head circumference in affected MZ co-twins (relative to unaffected MZ co-twin) characteriazes discordant MZ pairs with larger finger-ridge-count differences (i.e., second-trimester fetal-size differences). This study using ideal genetic controls suggests that, while present only in some patients with schizophrenia, the decrease in head circumference is most likely a consequence of in-utero nonshared environmental deleterious events manifesting as groth retardation or as fetal edema and occurring around the fifth prenatal month.

Item Type:Journal (Paginated)
Keywords:Schizophrenia, Etiology, Embryology, Neurodevelopment, Dysmorphology, Dermatoglyphics, Twins, Monozygotic, Nonshared environment
Subjects:Neuroscience > Neuropsychiatry
Neuroscience > Neurology
ID Code:5300
Deposited By:Bracha, Stefan
Deposited On:22 Dec 2006
Last Modified:11 Mar 2011 08:56

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