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Comparison of insulin resistance by indirect methods - HOMA, QUICKI and McAuley - with fasting insulin in patients with type 2 diabetes in Galle,Sri Lanka: A pilot study

Menik Hettihewa, Dr. Lukshmy and Palangasinghe, Dr. Shalika and S Jayasinghe, Dr. Sudheera and W Gunasekara, Dr. Sudari and P Weerarathna, Dr. Thilak (2006) Comparison of insulin resistance by indirect methods - HOMA, QUICKI and McAuley - with fasting insulin in patients with type 2 diabetes in Galle,Sri Lanka: A pilot study. [Journal (On-line/Unpaginated)]

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Abstract

Background: To investigate importance of fasting insulin (FI) as a diagnostic test for insulin resistance (IR) and to compare with other standard methods McAuley (McA), HOMA and QUICKI indices in Diabetes Mellitus (DM). Method: 42 diabetic patients who have been already diagnosed were used in our study. They were investigated for fasting blood glucose (FBS), FI, LDL, Triglycerides (TG), total cholesterol (TC) and HDL levels. IR was calculated by McA, HOMA, QUICKI indices and by FI. Results: 81% of patients were insulin resistant by McA and FI in our study group. 93% were detected as insulin resistant by HOMA and QUICKI. IR by FI was further compared with HOMA and QUICKI and 81% of patients were found to be insulin resistant by FI, HOMA and QUICKI. Results showed that there was a significant correlation between FI and McA in expressing IR in our study group (p <0.01, r = -0.849). Further, FI had a statistically significant correlation with HOMA and QUICKI indices (p <0.01, r = 0.906 and p <0.01 r = -0.822 respectively). Conclusion: FI measurement alone in diabetic patients has detected IR in 81% of patients, similar to the other standard methods (McA; 81%, HOMA and QUICKI; 93%). We further identified that FI as a diagnostic test of IR had substantial correlation with McA. Our results recommend further studies to see the possibility of taking fasting insulin to determine IR in type 2 diabetic population

Item Type:Journal (On-line/Unpaginated)
Keywords:Insulin resistance, McAuley index, HOMA index, QUICKI index, Fasting insulin, Type 2 diabetes mellitus
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:5000
Deposited By:Kakkilaya Bevinje, Dr. Srinivas
Deposited On:16 Jul 2006
Last Modified:11 Mar 2011 08:56

References in Article

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1. DeFronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia, and atherosclerotic cardiovascular disease. Diabetes care 1991;14:173-194.

2. Ferrannani E. Insulin resistance is central to the burden of diabetes. Diabetes Metlab Rev 1997;13: 81-86.

3. Ferrannini E, Mari A. How to measure insulin sensitivity. J Hypertens 1998;16:895-906.

4. Bergman RN, Finegood DT, Ader M. Assessment of insulin sensitivity in vivo. Endocr Rev 1985;6:45-86.

5. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Teacher DF, Turner RC. Homeostasis model assessment: insulin resistance and b cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 1985;28:412-419.

6. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ. Quantitative insulin sensitivity check index: a simple, accurate method of assessing insulin sensitivity in humans. J. Clin. Endocrinol. Metab 2000;85:2402-2410.

7. McAuley KA, Williams SM, Mann JI, Walker RJ, Ledwis-Barned NJ, Temple LA, Duncan AS. Diagnosing insulin resistance in the general population. Diabetes Care 2001;24:460-464.

8. DeFronzo MRA. Insulin sensitivity indices obtained from oral glucose tolerance testing: comparison with the euglycaemic clamp. Diabetes Care 1999;22:1462-70.

9. Louise SC, Stewart GT, Wendy JB, Jennifer AB. Indexes of Insulin Resistance and Secretion in Obese Children and Adolescents. A validation study Diabetes Care 2004;27:314-319.

10. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MA, Monauni T, Muggeo M. Homeostasis Model Assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 2000;23:57-63.

11. Miyazaki Y, Matsuda M, DeFronzo RA. Dose response effect of pioglitazone on insulin sensitivity and insulin secretion in type 2 diabetes. Diabetes Care 2002;25:517-23.

12. Juan FA, Susana P, José TR, Rosario IL, Antonia P, Rafael C. Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism. Diabetes Care 2003;26:3320-3325.

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