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Effect of lithium on acetylcholine esterase activity, and isozyme pattern in developing chick brain

Gouri, Ms Anahita and Sathe, Ms Kinneri and Ramachandran, Dr Hema and Rajadhyaksha, Dr Medha (2004) Effect of lithium on acetylcholine esterase activity, and isozyme pattern in developing chick brain. [Conference Poster] (Unpublished)

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Abstract

Acetylcholine Esterase is an enzyme, which hydrolyses acetylcholine and is used as a marker for cholinergic neural function. It is known to be involved in synaptogenesis. While on one hand it is known to be a marker for the developing chick brain it is also implicated in neurodegenerative diseases. In vertebrates the protein is synthesized by a single gene and undergoes alternative splicing to give 6-8 isoforms. Isozyme patterns of acetylcholine esterase have been suggested to be useful prognostic markers of neuronal degeneration. Lithium a well-known teratogen is known to induce apoptosis in the developing chick brain. Understanding the dynamics of acetylcholine esterase isoform pattern in lithium induced neural tissue damage would help elucidating the role of these isoforms in frank neurodegenerative diseases. We have therefore studied activity and isozyme pattern of acetylcholine esterase in lithium treated and control 7 day old developing chick brain and report the same.

Item Type:Conference Poster
Additional Information:A platform presentation was delivered at the “ Joint International Neuroscience Conference” held in May 2004, at the university of Hyderabad. The author was honoured with the ‘D.M Kar - Young scientist 2004 award’. This project also received the 'Lady Tata Memorial Trust’ scholarship.
Keywords:Anahita Gouri, Acetylcholinesterase, Lithium Chloride, Invertebrate AChE, Vertebrate AChE, developing chick brain
Subjects:Neuroscience > Neurochemistry
ID Code:4668
Deposited By:Gouri, Ms Anahita
Deposited On:30 Dec 2005
Last Modified:11 Mar 2011 08:56

References in Article

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1)Ashwani V. (1992), Ph.D. thesis, University of Mumbai.

2)Ellman G.L., et al. (1961) Biochem. Pharmacol.7,88-95.

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