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Biological Pacemakers

G, Rajesh and Francis, Johnson (2005) Biological Pacemakers. [Journal (Paginated)]

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Abstract

Genetically engineered pacemakers could be a possible alternative to implantable electronic devices for the treatment of bradyarrhythmias. The strategies include upregulation of beta adrenergic receptors, conversion of myocytes into pacemaker cells and stem cell therapy. Pacemaker activity in adult ventricular myocytes is normally repressed by the inward rectifier potassium current (IK1). The IK1 current is encoded by the Kir2 gene family. Use of a negative construct that suppresses current when expressed with wild-type Kir2.1 is an experimental approach for genesis of genetic pacemaker. hyperpolarisation activated cyclic nucleotide gated (HCN) channels which generate If current, the pacemaker current of heart can be delivered to heart by using stem cell therapy approach and viral vectors. The unresolved issues include longevity and stability of pacemaker genes, limitations involved in adenoviral and stem cell therapy and creation of genetic pacemakers which can compete with the electronic units.

Item Type:Journal (Paginated)
Keywords:Gene therapy, Pacemaker current, HCN channels
Subjects:JOURNALS > Indian Pacing and Electrophysiology Journal
ID Code:4599
Deposited By:Indian Pacing and Electrophysiology, Journal
Deposited On:06 Jan 2006
Last Modified:11 Mar 2011 08:56

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