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Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation

Lukshmy Menik, Hettihewa and Sudheera Sammanthi, Jayasinghe and Thilak Priyantha, Weerarathna and Shalika, Palangasinghe and Kotapola, Imendra (2005) Genetic Association Between Insulin Resistance And Total Cholesterol In Type 2 Diabetes Mellitus - A Preliminary Observation. [Journal (On-line/Unpaginated)]

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Abstract

We investigated the degree of genetic association between insulin resistance (IR) with type 2 diabetes mellitus (DM) and abnormalities in lipid metabolism in 42 patients. IR was assessed by fasting insulin test (FI), McAuley (McA), HOMA and QUICKI methods. IR was detected in 34 (81%) patients by FI, McA and in 39 (93%) patients by HOMA and QUICKI. 26 (62%) patients had family history of DM and 23 (89%) of them displayed IR by FI & McA. 24 of them (92%) displayed IR by HOMA and QUICKI. Our results suggest that association between the family history of DM and IR were statistically significant by chi-square test (P<0.05). Further, 29 (69%) patients had elevated total cholesterol levels. Association between elevated total cholesterol and IR as assessed by FI test was also statistically significant (x2=4.6; p<0.05). Results of our study indicate the statistically significant genetic association of IR with abnormal cholesterol metabolism and family history of DM

Item Type:Journal (On-line/Unpaginated)
Keywords:Type 2 diabetes, Insulin resistance, McAuley index, Dyslipidaemia
Subjects:JOURNALS > Online Journal of Health and Allied Sciences
ID Code:4474
Deposited By: Kakkilaya Bevinje, Dr. Srinivas
Deposited On:15 Jul 2005
Last Modified:11 Mar 2011 08:56

References in Article

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1.De Fronzo RA. Lilly Lecture- The triumvirate: beta cell, muscle, liver, collusion responsible for NIDDM. Diabetes. 1987; 37:667-687.

2.Kobberling J, Tillil H. Empirical risk figures for first-degree relatives of non-insulin dependent diabetics in the genetics of diabetes mellitus. Academic press, 1982; p. 201-209.

3.Barnett AH, Eff C, Leslie RDG et al. Diabetes in identical twin: a study of 200 pairs. Diabetologia 1981; 20:87-93.

4.Hanefeld M, Leonhardt W, Eds. J & Gustar F, The metabolic Syndrome: roots, myths, and facts in the metabolic syndrome, 1977; p.13-24.

5.Isoma B, Almgren P, Tuomi T et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes care. 2001; 24:683-689.

6.Ford ES, Giles WH, Dietz WH. Prevalence of metabolic syndrome among US adults. JAMA 2002; 287:356-359.

7.Greenfield MS, Dobeme L, Kraemer F et al. Assessment of insulin resistance with the insulin suppression test and the euglycemic clamp. Diabetes care 1981; 30:387-392.

8.McAuley KA, Williams SM, Mann JI et al. Diagnosing insulin resistance in the general population. Diabetes care 2001; 24:460-464.

9.Katz A, Nambi SS, Mather K et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J clin Endocrinol Metab 2000; 85:2402-2410.

10.Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and ß cell function from fasting plasma glucose and insulin concentration in man. Diabetologia 1985; 28: 412-419.

11.Ascaso JF, Romero P, Real JT et al. Quantification of insulin resistance with the values of basal insulin and HOMA index in a non-diabetic population. Med clin (Barna) 2001; 117:530-533.

12.Ascaso JF, Susana P, Real JT et al. Diagnosing Insulin Resistance by Simple Quantitative Methods in Subjects With Normal Glucose Metabolism. Diabetes Care 2003; 3320-3325.

13.De Fronzo RA, Ferrannini E. Insulin resistance: a multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidaemia and atherosclerotic cardiovascular disease. Diabetic care 1991;14:173-194.

14.Meigs JB. Epidemiology of the metabolic syndrome. Am J Manag Care 2002; 8 (Suppl.11):S283–S296.

15.Ford ES, Giles WH, Dietz WH. Prevalence of metabolic syndrome among US adults. JAMA. 2002; 287:356–359.

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