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A continuum of psychosis, one human gene, and not much else - the case for homogeneity

Crow, Prof TJ (1995) A continuum of psychosis, one human gene, and not much else - the case for homogeneity. [Journal (Paginated)]

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Abstract

The contention of this paper is that psychoses are not a collection of separate and unrelated diseases, but a set of diverse expressions of a single underlying entity. It will be argued that there is a basic homogeneity of pathogenesis, that there are not multiple predisposing genes but a single gene that is associated with significant diversity. Therefore the problem is a unitary one. The challenge is to identify the nature and function of the gene. It will be argued that the gene is that by which homo sapiens has separated from other primate species, and that the diversity arises from selective pressures which continue to act on this specifically human gene.

Item Type:Journal (Paginated)
Keywords:Manic-depressive psychosis; Evolution; Continuum; Sexual selection; Asymmetry; (Schizophrenia)
Subjects:Neuroscience > Neurogenetics
ID Code:3904
Deposited By: Crow, Prof Tim
Deposited On:28 Oct 2004
Last Modified:11 Mar 2011 08:55

References in Article

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Angst, J., Scharfetter, C. and Stassen, H.H., 1983. Classification of schizo-affective patients by multidimensional scaling and cluster analysis. Psychiat Clin (Basel) 16, pp. 254–264. Abstract-EMBASE | Abstract-PsycINFO | Abstract-MEDLINE

Annett, M., 1985. Left, Right, Hand and Brain. , Lawrence Erlbaum, London.

Astrachan, B.M., Harrow, M., Adler, D. et al., 1972. A checklist for the diagnosis of schizophrenia. Br J Psychiatry 121, pp. 529–539. Abstract-PsycINFO | Abstract-MEDLINE

Bear, D.M., Schiff, D., Saver, J., Greenberg, M. and Freeman, R., 1986. Quantitative analysis of cerebral asymmetry; fronto-occipital correlation, sexual dimorphism and association with handedness. Arch Neurol 43, pp. 598–603. Abstract-MEDLINE | Abstract-EMBASE

Bilder, R.M., Wu, H., Bogerts, B., Degreef, G., Ashtari, M., Alivir, J.M.J., Snyder, P.J. and Lieberman, J.A., 1994. Absence of regional hemispheric volume asymmetries in first episode schizophrenia. Am J Psychiatry 151, pp. 1437–1447. Abstract-EMBASE | Abstract-MEDLINE | Abstract-PsycINFO

Book, J.A., Wetterburg, L. and Modrzewska, K., 1978. Schizophrenia in a North Swedish geographic isolate, 1900–1977. Clin Genet 14, pp. 373–394. Abstract-MEDLINE | Abstract-EMBASE

Brown, R., Colter, N., Corsellis, J.A.N. et al., 1986. Post-mortem evidence of structural brain changes in schizophrenia. Arch Gen Psychiatry 43, pp. 36–42. Abstract-MEDLINE | Abstract-EMBASE | Abstract-PsycINFO

Buss, D.M. et al., 1990. International preferences in selecting mates, a study of 37 cultures. J Cross-Cultural Psychol 21, pp. 5–47. Abstract-PsycINFO

Cabot, M.R., 1990. The incidence and prevalence of schizophrenia in the Republic of Ireland. Soc Psychiatry Psychiatric Epidem 25, pp. 210–215. Abstract-PsycINFO | Abstract-EMBASE | Abstract-MEDLINE

Cannon, M., Cotter, D., Sham, P.C. et al., 1994. Schizophrenia in an Irish sample following prenatal exposure to the 1957 epidemic: a case-controlled, prospective follow-up study. Schizophr Res 11, p. 95.

Chen, H.M., Lowther, W., Avramopoulos, D. and Antonorakis, S.E., 1994. Homologous loci DXYS156X and DXYS156Y contain a polymorphic pentanucleotide repeat (TAAAA) and map to human X chromosome and Y chromosome. Hum Mut 4, pp. 208–211. Abstract-MEDLINE | Abstract-EMBASE | Abstract-Elsevier BIOBASE

Cloninger, C.R., Martin, R.L., Guze, S.B. and Clayton, P.J., 1985. Diagnosis and prognosis in schizophrenia. Arch Gen Psychiatry 42, pp. 15–25. Abstract-MEDLINE | Abstract-EMBASE | Abstract-PsycINFO

Cloninger, C.R., 1994. Pro: tests of alternative models of the relationship of schizophrenic and affective psychoses. In: Gershon, E.G. and Cloninger, C.R., Editors, 1994. Genetic Approaches to Mental Disorders, American Psychiatric Press, Washington, pp. 149–162. Abstract-PsycINFO

Cooper, B., 1994. Folnegovic and Folnegovic-Smalc's ‘Schizophrenia in Croatia: Inter-regional differences in prevalence and a comment on constant incidence’. Br J Psychiatry 164, pp. 97–99.

Corballis, M.C., 1991. The Lop-sided Ape: Evolution of the Generative Mind. , Oxford University Press, New York.

Corballis, M.C., Lee, K., McManus, I.C. and Crow, T.J., 1995. Location of the handedness gene on the X and Y chromosomes. Neuropsychiat Genet (in press) .

Crocetti, G.M., Kulcar, Z., Kesic, B. and Lemkau, P.V., 1964. Differential rates of schizophrenia in Croatia (Yugoslavia). Am J Public Health 54, pp. 196–206.

Crow, T.J., 1986. The continuum of psychosis and its implication for the structure of the gene. Br J Psychiatry 149, pp. 419–429. Abstract-PsycINFO | Abstract-MEDLINE | Abstract-EMBASE

Crow, T.J., Ball, J., Bloom, S.R., Brown, R., Bruton, C.J., Colter, N., Frith, C.D., Johnstone, E.C., Owens, D.G. and Roberts, G.W., 1989. Schizophrenia as an anomaly of development of cerebral asymmetry. A postmortem study and a proposal concerning the genetic basis of the disease. Arch Gen Psychiatry 46, pp. 1145–1150. Abstract-PsycINFO | Abstract-EMBASE | Abstract-MEDLINE

Crow, T.J., Colter, N., Frith, C.D., Johnstone, E.C. and Owens, D.G.C., 1989. Developmental arrest of cerebral asymmetries in early onset schizophrenia. Psychiatry Res 29, pp. 247–253. Abstract

Crow, T.J., 1990. Nature of the genetic contribution to psychotic illness — a continuum viewpoint. Acta Psychiatr Scand 81, pp. 401–408. Abstract-PsycINFO | Abstract-EMBASE | Abstract-MEDLINE

Crow, T.J., 1993. Sexual selection, Machiavellian intelligence and the origins of psychosis. Lancet 342, pp. 594–598. Abstract

Crow, T.J., 1993. Origins of psychosis and the evolution of human language and communication. In: Langer, S., Mendlewicz, J. and Racagni, J., Editors, 1993. New Generation of Antipsychotic Drugs: Novel Mechanisms of Action, Karger, Basel, pp. 39–61.

Crow, T.J., 1994. The case for an X-Y homologous determinant of cerebral asymmetry. Cytogenet Cell Genet 67, pp. 393–394.

Crow, T.J., 1994. Prenatal exposure to influenza as a cause of schizophrenia; there are inconsistencies and contradictions in the evidence. Br J Psychiatry 164, pp. 588–592. Abstract-MEDLINE | Abstract-PsycINFO

Crow, T.J., 1995. The Darwinian approach to the origins of psychosis. Br J Psychiatry 167, pp. 12–25. Abstract-MEDLINE | Abstract-PsycINFO | Abstract-EMBASE

Crow, T.J., 1995. Psychotic continuum or disease entities? The critical impact of nosology on the problem of aetiology. In: Marneros, A., Andreasen, N.C. and Tsuang, M.T., Editors, 1995. Psychotic Continuum, Springer-Verlag, Berlin, pp. 151–163.

Crow, T.J. and Done, D.J., 1992. Prenatal exposure to influenza does not cause schizophrenia. Br J Psychiatry 161, pp. 390–393. Abstract-MEDLINE | Abstract-EMBASE | Abstract-PsycINFO

Daniel, D.G., Goldberg, T.E., Gibbons, R.D. and Weinberger, D.R., 1991. Lack of a bimodal distribution of ventricular size in schizophrenia: A Gaussian mixture analysis of 1056 cases and controls. Biol Psychiatry 30, pp. 886–903.

Darwin, C., 1871. The Descent of Man, and Selection in Relation to Sex. In: , Princeton University Press, New Jersey, pp. 390–402 (facsimile of original published by J Murray in 1981, London) .

Der, G., Gupta, S. and Murray, R.M., 1990. Is schizophrenia disappearing?. Lancet 335, pp. 513–516. Abstract

Done, D.J., Johnstone, E.C., Frith, C.D., Golding, J., Shepherd, P.M. and Crow, T.J., 1991. Complications of pregnancy and delivery in relation to psychosis in adult life: data from the British perinatal mortality survey sample. Br Med J 302, pp. 1576–1580. Abstract-MEDLINE | Abstract-EMBASE

Eagles, J.M. and Whalley, L.J., 1985. Decline in the diagnosis of schizophrenia among first admissions to Scottish mental hospitals from 1969–1978. Br J Psychiatry 146, pp. 151–154. Abstract-EMBASE | Abstract-MEDLINE | Abstract-PsycINFO

Endicott, J., Nee, J., Fleiss, J., Cohen, J., Williams, J.B.W. and Simon, R., 1982. Diagnostic criteria for schizophrenia: reliabilities and agreement between systems. Arch Gen Psychiatry 39, pp. 884–889. Abstract-PsycINFO | Abstract-EMBASE | Abstract-MEDLINE

Folnegovic, Z. and Folnegovic-Smalc, V., 1992. Schizophrenia in Croatia: interregional differences in prevalence and a comment on constant incidence. J Epidemiol Community Health 46, pp. 248–255. Abstract-EMBASE | Abstract-GEOBASE | Abstract-PsycINFO

Gershon, E.S., Hamovit, J., Guroff, J.J., Dibble, E., Leckmann, J.F., Sceery, W., Targum, S.D., Nurnberger, J.I., Goldin, L.R. and Bunney, W.E., 1982. A family study of schizo-affective, bipolar I, bipolar II, unipolar and normal control patients. Arch Gen Psychiatry 39, pp. 1157–1167. Abstract-EMBASE | Abstract-PsycINFO | Abstract-MEDLINE

Gershon, E.S., DeLisi, L.E., Hamovit, J., Nurnberger, J.I., Maxwell, M.E., Schreiber, J., Dauphinais, D., Dingman, C.W. and Guroff, J.J., 1988. A controlled family study of chronic psychoses: schizophrenia and schizo-affective disorder. Arch Gen Psychiatry 45, pp. 328–336. Abstract-EMBASE | Abstract-PsycINFO | Abstract-MEDLINE

Glover, G., 1993. Sex ratio errors in census data. Br Med J 307, p. 506. Abstract-EMBASE | Abstract-MEDLINE

Halpern, D.F., 1992. Sex Differences in Cognitive Abilities. , L. Erlbaum, Hillside, New Jersey.

Harrison, G., 1991. Searching for the causes of schizophrenia: the role of migrant studies. Schizophr Bull 16, pp. 663–671.

Harvey, I., McGuffin, P., Williams, M. and Toone, B.K., 1990. The ventricle-brain ratio (VBR) in functional psychoses: an admixture analysis. Psych Res Neuroim 35, pp. 61–69. Abstract

Jablensky, A., Sartorius, N., Ernberg, G., Anker, M., Korten, A., Cooper, J.E., Day, R. and Bertelsen, A., 1992. Schizophrenia: manifestations, incidence and course in different cultures. A World Health Organization ten country study. Psychol Med Suppl 20, pp. 1–97. Abstract-EMBASE | Abstract-MEDLINE

Johnstone, E.C., Crow, T.J., Frith, C.D., Husband, J. and Kreel, L., 1976. Cerebral ventricular size and cognitive impairment in chronic schizophrenia. Lancet ii, pp. 924–926. Abstract

Johnstone, E.C., Owens, D.G., Bydder, G.M., Colter, N., Crow, T.J. and Frith, C.D., 1989. The spectrum of structural brain changes in schizophrenia: age of onset as a predictor of cognitive and clinical impairments and their cerebral correlates. Psychol Med 19, pp. 91–103. Abstract-PsycINFO | Abstract-EMBASE | Abstract-MEDLINE

Karlsson, J.L., 1974. Inheritance of schizophrenia. Acta Psychiatr Scand Suppl 274, pp. 1–116. Abstract-MEDLINE

Kasanin, J., 1933. The acute schizo-affective psychoses. Am J Psychiatry 90, pp. 97–126.

Kelleher, M.J., Copeland, J.R.M. and Smith, A.J., 1974. High first admission rates for schizophrenia in the West of Ireland. Psychol Med 4, pp. 460–462. Abstract-PsycINFO | Abstract-EMBASE | Abstract-MEDLINE

Kendell, R.E., 1987. Diagnosis and classification of functional psychoses. Br Med Bull 43, p. 4997.

Kendell, R.E., Malcolm, D.E. and Adams, W., 1988. The problem of detecting changes in the incidence of schizophrenia. Br J Psychiatry 152, pp. 793–798.

Kendell, R.E. and Gourlay, J., 1970. The clinical distinction between the affective psychoses and schizophrenia. Br J Psychiatry 117, pp. 261–266. Abstract-MEDLINE | Abstract-PsycINFO

Kendler, K.S., McGuire, M., Gruenberg, A.M., O'Hare, A., Spellman, M. and Walsh, D., 1993. The Roscommon family study I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 50, pp. 527–540. Abstract-EMBASE | Abstract-MEDLINE | Abstract-PsycINFO

Kendler, K.S., Neale, M.C. and Walsh, D., 1995. Evaluating the spectrum concept of schizophrenia in the Roscommon family study. Am J Psychiatry 152, pp. 749–754. Abstract-PsycINFO | Abstract-EMBASE | Abstract-MEDLINE

Kraepelin, E., 1919. Dementia Praecox and Paraphrenia. In: , Krieger, New York (translated by R M Barclay, facsimile edition published in 1971) .

Kraepelin, E., 1920. Die Erscheinungsformen des Irreseins. In: Hirsch, S.R. and Shepherd, M., Editors, 1920. Themes and Variations in European Psychiatry (Patterns of mental disorder), Wright, Bristol, pp. 7–30 translated by H Marshall as: .

Kraepelin, E., 1920. Zeit Gesam Neurol Psychiatrie 62, pp. 1–29.

Lambson, B., Affara, N.A., Mitchell, M. and Ferguson-Smith, M.A., 1992. Evolution of DNA sequence homologies between the sex chromosomes in primate species. Genomics 14, pp. 1032–1040. Abstract-EMBASE | Abstract-MEDLINE

Lemkau, P.V., Kulcar, Z., Crocetti, G.M. and Kesic, B., 1971. Selected aspects of the epidemiology of psychoses in Croatia, Yugoslavia. I. Background and use of psychiatric hospital statistics. Am J Epidemiol 94, pp. 112–117. Abstract-MEDLINE

Maier, W., Lichtermann, D., Minges, J., Hallmayer, J., Henn, R., Benkert, O. and Levinson, D.F., 1993. Continuity and discontinuity of affective disorders and schizophrenia. Arch Gen Psychiatry 50, pp. 871–883. Abstract-PsycINFO | Abstract-MEDLINE | Abstract-EMBASE

Maier, W. and Lichtermann, D., 1991. The interrelationship of major psychotic disorder as evidenced by patterns of familial transmission. In: Racagni, G., Brunello, N. and Fukuda, T., Editors, 1991. Biological Psychiatry, Elsevier, Amsterdam, pp. 503–505.

Marneros, A., Rohde, A. and Deister, A., 1995. Psychotic continuum under longitudinal considerations. In: Marneros, A., Andreasen, N.C. and Tsuang, M.T., Editors, 1995. Psychotic Continuum, Springer-Verlag, Berlin, pp. 17–30.

McGlone, J., 1980. Sex differences in human brain asymmetry: a critical survey. Behav Brain Sci 3, pp. 215–263. Abstract-PsycINFO | Abstract-EMBASE

McManus, I.C., 1985. Handedness, language dominance and aphasia: a genetic model. Psychol Med Monogr Suppl 8, pp. 1–40. Abstract-MEDLINE

McManus, I.C., Shergill, S. and Bryden, M.P., 1993. Annett's theory that individuals heterozygous for the right shift gene are intellectually advantaged: theoretical and empirical findings. Br J Psychol 84, pp. 517–537. Abstract-PsycINFO | Abstract-MEDLINE

Ni Nuallain, M., O'Hare, A. and Walsh, D., 1990. The prevalence of schizophrenia in three counties in Ireland. Acta Psychiatr Scand 82, pp. 136–140. Abstract-MEDLINE

Odegaard, O., 1972. The multifactorial inheritance of predisposition to schizophrenia. In: Kaplan, A.R., Editor, , 1972. Genetic Factors in ‘Schizophrenia’, Thomas, Springfield, pp. 256–275.

Owens, D.G.C., Johnstone, E.C., Crow, T.J., Frith, C.D., Jagoe, J.R. and Kreel, L., 1985. Cerebral ventricular enlargement in schizophrenia: relationship to the disease process and its clinical correlates. Psychol Med 15, pp. 27–41. Abstract-MEDLINE | Abstract-EMBASE | Abstract-PsycINFO

Pakkenberg, B., 1987. Postmortem study of chronic schizophrenic brains. Br J Psychiatry 151, pp. 744–752. Abstract-EMBASE | Abstract-PsycINFO | Abstract-MEDLINE

Pearlson, G.D., Kim, W.S., Kubos, K.L., Moberg, P.J., Jayaram, G., Bascom, M.J., Chase, G.A., Goldfinger, A.D. and Tune, L.E., 1989. Ventricle-brain ratio, computed tomographic density, and brain area in 50 schizophrenics. Arch Gen Psychiatry 46, pp. 690–697. Abstract-MEDLINE | Abstract-PsycINFO | Abstract-EMBASE

Penrose, L.S., 1991. Survey of cases of familial mental illness. Eur Arch Psychiatry Neurol Sci 240, pp. 315–324. Abstract-EMBASE | Abstract-PsycINFO

Ron, M.A., Harvey, I., Lewis, S. and Murray, R., 1992. Diffuse structural brain abnormalities in schizophrenia. Schizophr Res 6, p. 145. Abstract

Stassen, H.H., Scharfetter, C., Winokur, G. and Angst, J., 1988. Familial syndrome patterns in schizophrenia, schizoaffective disorder, mania, and depression. Eur Arch Psychiatry Neurol Sci 237, pp. 115–123. Abstract-EMBASE | Abstract-PsycINFO | Abstract-MEDLINE

Stoll, A.L., Tohen, M., Baldessarini, R.J., Goodwin, D.C., Stein, S., Katz, S., Geeneus, D., Swinson, R.P., Goethe, J.W. and McGlashan, T., 1993. Shifts in diagnostic frequences of schizophrenia and major affective disorders at six North American Psychiatric Hospitals, 1972–1988. Am J Psychiatry 150, pp. 1668–1673. Abstract-EMBASE | Abstract-PsycINFO | Abstract-MEDLINE

Taylor, M.A., Berenbaum, S.A., Jampala, V.C. and Cloninger, C.R., 1993. Are schizophrenia and affective disorder related? Preliminary data from a family study. Am J Psychiatry 150, pp. 278–285. Abstract-EMBASE | Abstract-MEDLINE | Abstract-PsycINFO

Taylor, M.D. and Abrams, R., 1975. A critique of the St Louis psychiatric research criteria for schizophrenia. Am J Psychiatry 132, pp. 1276–1280. Abstract-EMBASE | Abstract-PsycINFO | Abstract-MEDLINE

Tooby, J. and Cosmides, L., 1990. On the universality of human nature and the uniqueness of the individual — the role of genetics and adaptation. J Pers 58, pp. 17–67. Abstract-PsycINFO | Abstract-MEDLINE

Torrey, E.F., Bowler, A.E., Taylor, E.H. and Gottesman, I.I., 1994. Schizophrenia and Manic-Depressive Disorder. , Basic Books, New York.

Turner, T.H., 1992. Schizophrenia as a permanent problem: some aspects of historical evidence in the recency (new disease) hypothesis. Hist Psychiatry 3, pp. 413–429. Abstract-MEDLINE | Abstract-PsycINFO

Walsh, D. and Walsh, B., 1970. Mental illness in the Republic of Ireland — first admissions. J Irish Med Assoc 63, pp. 365–370. Abstract-MEDLINE

Weinberger, D.R., Torrey, E.F., Neophytides, A.N. and Wyatt, R.T., 1979. Lateral cerebral ventricular enlargement in chronic schizophrenia. Arch Gen Psychiatry 36, pp. 735–739. Abstract-MEDLINE | Abstract-EMBASE

Wessely, S., Castle, D., Der, G. and Murray, R.M., 1991. Schizophrenia and Afro-Caribbeans, a case control study. Br J Psychiatry 159, pp. 795–801. Abstract-EMBASE | Abstract-MEDLINE | Abstract-PsycINFO

Zipursky, R.B., Lim, K.O., Sullivan, E.V., Brown, B.W. and Pfefferbaum, A., 1992. Widespread cerebral grey matter volume deficits in schizophrenia. Arch Gen Psychiatry 49, pp. 195–205. Abstract-EMBASE | Abstract-MEDLINE | Abstract-PsycINFO

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