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Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes

Crusio, Wim E. (1993) Bi- and Multivariate Analyses of Diallel Crosses: A Tool for the Genetic Dissection of Neurobehavioral Phenotypes. [Journal (Paginated)]

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Abstract

The genetic-correlational approach provides a very powerful tool for the analysis of causal relationships between phenotypes. It appears to be particularly appropriate for investigating the functional organization of behavior and/or of causal relationships between brain and behavior. A method for the bivariate analysis of diallel crosses that permits the estimation of correlations due to environmental effects, additive-genetic effects, and/or dominance deviations is described, together with a worked-out example stemming from a five times replicated 4 x 4 diallel cross between inbred mouse strains. The phenotypes chosen to illustrate the analysis were locomotor activity and rearing frequency in an open field. Large, positive additive-genetic and dominance correlations between these two phenotypes were obtained. This finding was replicated in another, independently-executed, diallel cross.

Item Type:Journal (Paginated)
Keywords:diallel cross, genetic correlations, multivariate analysis, brain-behavior relationships, neurobehavioral genetics, exploratory activity, mouse
Subjects:Neuroscience > Behavioral Neuroscience
ID Code:33
Deposited By:Crusio, Wim E
Deposited On:07 May 1998
Last Modified:11 Mar 2011 08:53

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