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Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity

Scheler, Dr. Gabriele (2003) Regulation of Neuromodulator Receptor Efficacy- Implications for Whole-Neuron and Synaptic Plasticity. [Preprint]

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Abstract

Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental factors, its functional consequences and modes of action are not well understood. In this paper we summarize relevant experimental evidence on NM receptor regulation (specifically dopamine D1 and D2 receptors) in order to explore its significance for neural and synaptic plasticity. We identify the relevant components of NM receptor regulation (receptor phosphorylation, receptor trafficking and sensitization of second-messenger pathways) gained from studies on cultured cells. Key principles in the regulation and control of short-term plasticity (sensitization) are identified, and a model is presented which employs direct and indirect feedback regulation of receptor efficacy. We also discuss long-term plasticity which involves shifts in receptor sensitivity and loss of responsivity to NM signals. Finally, we discuss the implications of NM receptor regulation for models of brain plasticity and memorization.We emphasize that a realistic model of brain plasticity will have to go beyond Hebbian models of long-term potentiation and depression to include plasticity in the distribution and efficacy of NM receptors.

Item Type:Preprint
Keywords:Hebbian plasticity, neuromodulators, dopamine, metaplasticity, LTP, learning, regulatory networks
Subjects:Neuroscience > Computational Neuroscience
Biology > Theoretical Biology
Neuroscience > Neuropharmacology
ID Code:2836
Deposited By:Scheler, Gabriele
Deposited On:17 Mar 2003
Last Modified:12 Sep 2007 17:47

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

[AbrahamBear96]

W C Abraham and M F Bear.

Metaplasticity: the plasticity of synaptic plasticity.

Trends Neurosci, 19:126-30, 1996.

[AizmanOetal2000]

O Aizman, H Brismar, P Uhlen, E Zettergren, A I Levey, H Forssberg,

P Greengard, and A Aperia.

Anatomical and physiological evidence for D1 and D2 dopamine

receptor colocalization in neostriatal neurons.

Nat Neurosci, 3:226-30, 2000.

[BatesMDetal91]

M D Bates, M G Caron, and J R Raymond.

Desensitization of DA1 dopamine receptors coupled to adenylyl

cyclase in opossum kidney cells.

Am J Physiol, 260:F937-45, 1991.

[BatesMDetal93]

M D Bates, C L Olsen, B N Becker, F J Albers, J P Middleton, J G Mulheron, S L

Jin, M Conti, and J R Raymond.

Elevation of cAMP is required for down-regulation, but not

agonist-induced desensitization, of endogenous dopamine D1 receptors in

opossum kidney cells. Studies in cells that stably express a rat cAMP

phosphodiesterase (rPDE3) cDNA.

J Biol Chem, 268:14757-63, 1993.

[BehrJetal2000]

J Behr, T Gloveli, D Schmitz, and U Heinemann.

Dopamine depresses excitatory synaptic transmission onto rat

subicular neurons via presynaptic D1-like dopamine receptors.

J Neurophysiol, 84:112-9, 2000.

[BeurrierMalenka2002]

Corinne Beurrier and Robert C Malenka.

Enhanced inhibition of synaptic transmission by dopamine in the

nucleus accumbens during behavioral sensitization to cocaine.

J Neurosci, 22:5817-22, 2002.

[Bhalla2003]

Upinder S Bhalla.

Understanding complex signaling networks through models and

metaphors.[BindaAVetal2002]

Alicia V Binda, Nadine Kabbani, Ridwan Lin, and Robert Levenson.

D2 and D3 dopamine receptor cell surface localization mediated by

interaction with protein 4.1N.

Mol Pharmacol, 62:507-13, 2002.

[BlackLEetal94]

L E Black, E M Smyk-Randall, and D R Sibley.

Cyclic AMP-mediated desensitization of D1 dopamine receptor-coupled

adenylyl cyclase in NS20Y neuroblastoma cells.

Mol Cell Neurosci, 5:567-75, 1994.

[BlakelyBauman2000]

R D Blakely and A L Bauman.

Biogenic amine transporters: regulation in flux.

Curr Opin Neurobiol, 10:328-36, 2000.

[BlondOetal2002]

Olivier Blond, Francis Crepel, and Satoru Otani.

Long-term potentiation in rat prefrontal slices facilitated by

phased application of dopamine.

Eur J Pharmacol, 438:115-6, 2002.

[BouvierMetal88]

M Bouvier, W P Hausdorff, A De Blasi, B F O'Dowd, B K Kobilka, M G Caron, and

R J Lefkowitz.

Removal of phosphorylation sites from the beta 2-adrenergic receptor

delays onset of agonist-promoted desensitization.

Nature, 333:370-3, 1988.

[BursteinESetal97]

E S Burstein, T A Spalding, and M R Brann.

Pharmacology of muscarinic receptor subtypes constitutively

activated by G proteins.

Mol Pharmacol, 51:312-9, 1997.

[CaiGetal2002]

Guoping Cai, Hoau-Yan Wang, and Eitan Friedman.

Increased dopamine receptor signaling and dopamine receptor-G

protein coupling in denervated striatum.

J Pharmacol Exp Ther, 302:1105-12, 2002.

[CantrellARetal99]

A R Cantrell, T Scheuer, and W A Catterall.

Voltage-dependent neuromodulation of Na+ channels by D1-like

dopamine receptors in rat hippocampal neurons.

J Neurosci, 19:5301-10, 1999.

[CarmanBenovic98]

C V Carman and J L Benovic.

G-protein-coupled receptors: turn-ons and turn-offs.

Curr Opin Neurobiol, 8:335-44, 1998.

[CepedaCetal93]

C Cepeda, N A Buchwald, and M S Levine.

Neuromodulatory actions of dopamine in the neostriatum are dependent

upon the excitatory amino acid receptor subtypes activated.

Proc Natl Acad Sci U S A, 90:9576-80, 1993.

[ChenJCetal99]

J C Chen, H J Su, L I Huang, and M M Hsieh.

Reductions in binding and functions of D2 dopamine receptors in the

rat ventral striatum during amphetamine sensitization.

Life Sci, 64:343-54, 1999.

[ChenXetal99]

X Chen, S B Kombian, J A Zidichouski, and Q J Pittman.

Dopamine depresses glutamatergic synaptic transmission in the rat

parabrachial nucleus in vitro.

Neuroscience, 90:457-68, 1999.

[ChuangTTetal96]

T T Chuang, L Paolucci, and A De Blasi.

Inhibition of G protein-coupled receptor kinase subtypes by

Ca2+/calmodulin.

J Biol Chem, 271:28691-6, 1996.

[ColginLLetal2003]

Laura Lee Colgin, Don Kubota, and Gary Lynch.

Cholinergic plasticity in the hippocampus.

Proc Natl Acad Sci U S A, 100:2872-7, 2003.

[CummingPetal2002]

Paul Cumming, Dean F Wong, Robert F Dannals, Nic Gillings, John Hilton, Ursula

Scheffel, and Albert Gjedde.

The competition between endogenous dopamine and radioligands for

specific binding to dopamine receptors.

Ann N Y Acad Sci, 965:440-50, 2002.

[DelgadoAetal2000]

A Delgado, A Sierra, E Querejeta, R F Valdiosera, and J Aceves.

Inhibitory control of the GABAergic transmission in the rat

neostriatum by D2 dopamine receptors.

Neuroscience, 95:1043-8, 2000.[DemchyshynLLetal2000]

L L Demchyshyn, F McConkey, and H B Niznik.

Dopamine D5 receptor agonist high affinity and constitutive activity

profile conferred by carboxyl-terminal tail sequence.

J Biol Chem, 275:23446-55, 2000.

[EgorovAVetal2002]

Alexei V Egorov, Bassam N Hamam, Erik Fransen, Michael E Hasselmo, and Angel A

Alonso.

Graded persistent activity in entorhinal cortex neurons.

Nature, 420:173-8, 2002.

[EnnisMetal2001]

M Ennis, F M Zhou, K J Ciombor, V Aroniadou-Anderjaska, A Hayar, E Borrelli,

L A Zimmer, F Margolis, and M T Shipley.

Dopamine D2 receptor-mediated presynaptic inhibition of olfactory

nerve terminals.

J Neurophysiol, 86:2986-97, 2001.

[FedericiMetal2002]

Mauro Federici, Silvia Natoli, Giorgio Bernardi, and Nicola B Mercuri.

Dopamine selectively reduces GABA(B) transmission onto dopaminergic

neurones by an unconventional presynaptic action.

J Physiol, 540:119-28, 2002.

[FergusonSS2001]

S S Ferguson.

Evolving concepts in G protein-coupled receptor endocytosis: the

role in receptor desensitization and signaling.

Pharmacol Rev, 53:1-24, 2001.

[Flores-HernandezJ1etal2002]

Jorge Flores-Hernandez, Carlos Cepeda, Elizabeth Hernandez-Echeagaray,

Christopher R Calvert, Eve S Jokel, Allen A Fienberg, Paul Greengard, and

Michael S Levine.

Dopamine enhancement of NMDA currents in dissociated medium-sized

striatal neurons: role of D1 receptors and DARPP-32.

J Neurophysiol, 88:3010-20, 2002.

[GaoWJetal2001]

W J Gao, L S Krimer, and P S Goldman-Rakic.

Presynaptic regulation of recurrent excitation by D1 receptors in

prefrontal circuits.

Proc Natl Acad Sci U S A, 98:295-300, 2001.

[GardnerBetal2001]

B Gardner, Z F Liu, D Jiang, and D R Sibley.

The role of phosphorylation/dephosphorylation in agonist-induced

desensitization of D1 dopamine receptor function: evidence for a novel

pathway for receptor dephosphorylation.

Mol Pharmacol, 59:310-21, 2001.[GeurtsMetal2002]

Muriel Geurts, Emmanuel Hermans, and Jean Marie Maloteaux.

Opposite modulation of regulators of G protein signalling-2 (RGS2)

and RGS4 expression by dopamine receptors in the rat striatum.

Neurosci Lett, pages 146-50, 2002.

[GoldmanMSetal2001]

M S Goldman, J Golowasch, E Marder, and L F Abbott.

Global structure, robustness, and modulation of neuronal models.

J Neurosci, 21:5229-38, 2001.

[Gonzalez-IslasHablitz2001]

C Gonzalez-Islas and J J Hablitz.

Dopamine inhibition of evoked IPSCs in rat prefrontal cortex.

J Neurophysiol, 86:2911-8, 2001.

[GrotewielSanders-Bush99]

M S Grotewiel and E Sanders-Bush.

Differences in agonist-independent activity of 5-Ht2A and 5-HT2c

receptors revealed by heterologous expression.

Naunyn Schmiedebergs Arch Pharmacol, 359:21-7, 1999.

[GurevichEVetal2001]

E V Gurevich, R T Robertson, and J N Joyce.

Thalamo-cortical afferents control transient expression of the

dopamine D(3) receptor in the rat somatosensory cortex.

Cereb Cortex, 11:691-701, 2001.

[HagaKetal97]

K Haga, H Tsuga, and T Haga.

Ca2+-dependent inhibition of G protein-coupled receptor kinase 2 by

calmodulin.

Biochemistry, 36:1315-21, 1997.

[HarveyLacey96]

J Harvey and M G Lacey.

Endogenous and exogenous dopamine depress EPSCs in rat nucleus

accumbens in vitro via D1 receptors activation.

J Physiol, 492:143-54, 1996.

[HausdorffWPetal90]

W P Hausdorff, M J Lohse, M Bouvier, S B Liggett, M G Caron, and R J Lefkowitz.

Two kinases mediate agonist-dependent phosphorylation and

desensitization of the beta 2-adrenergic receptor.

Symp Soc Exp Biol, 44:225-40, 1990.

[HenryDJetal98]

D J Henry, X T Hu, and F J White.

Adaptations in the mesoaccumbens dopamine system resulting from

repeated administration of dopamine D1 and D2 receptor-selective agonists:

relevance to cocaine sensitization.

Psychopharmacology (Berl), 140:233-42, 1998.

[HenryWhite95]

D J Henry and F J White.

The persistence of behavioral sensitization to cocaine parallels

enhanced inhibition of nucleus accumbens neurons.

J Neurosci, 15:6287-99, 1995.

[Hernandez-LopezSetal97]

S Hernandez-Lopez, J Bargas, D J Surmeier, A Reyes, and E Galarraga.

D1 receptor activation enhances evoked discharge in neostriatal

medium spiny neurons by modulating an L-type Ca2+ conductance.

J Neurosci, 17:3334-42, 1997.

[HsuKS96]

K S Hsu.

Characterization of dopamine receptors mediating inhibition of

excitatory synaptic transmission in the rat hippocampal slice.

J Neurophysiol, 76:1887-95, 1996.

[HsuKSetal95]

K S Hsu, C C Huang, C H Yang, and P W Gean.

Presynaptic D2 dopaminergic receptors mediate inhibition of

excitatory synaptic transmission in rat neostriatum.

Brain Res, 690:264-8, 1995.

[HuXTetal2002]

Xiu-Ti Hu, Timothy E Koeltzow, Donald C Cooper, George S Robertson, Francis J

White, and Paul Vezina.

Repeated ventral tegmental area amphetamine administration alters

dopamine D1 receptor signaling in the nucleus accumbens.

Synapse, 45:159-70, 2002.

[JakabGoldman-Rakic2000]

R L Jakab and P S Goldman-Rakic.

Segregation of serotonin 5-HT2A and 5-HT3 receptors in inhibitory

circuits of the primate cerebral cortex.

J Comp Neurol, 417:337-48, 2000.

[JeongIkeda2000]

S W Jeong and S R Ikeda.