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Subthreshold dynamics of the neural membrane potential driven by stochastic synaptic input

Hillenbrand, Dr. Ulrich (2002) Subthreshold dynamics of the neural membrane potential driven by stochastic synaptic input. [Journal (On-line/Unpaginated)]

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Abstract

In the cerebral cortex, neurons are subject to a continuous bombardment of synaptic inputs originating from the network's background activity. This leads to ongoing, mostly subthreshold membrane dynamics that depends on the statistics of the background activity and of the synapses made on a neuron. Subthreshold membrane polarization is, in turn, a potent modulator of neural responses. The present paper analyzes the subthreshold dynamics of the neural membrane potential driven by synaptic inputs of stationary statistics. Synaptic inputs are considered in linear interaction. The analysis identifies regimes of input statistics which give rise to stationary, fluctuating, oscillatory, and unstable dynamics. In particular, I show that (i) mere noise inputs can drive the membrane potential into sustained, quasiperiodic oscillations (noise-driven oscillations), in the absence of a stimulus-derived, intraneural, or network pacemaker; (ii) adding hyperpolarizing to depolarizing synaptic input can increase neural activity (hyperpolarization-induced activity), in the absence of hyperpolarization-activated currents.

Item Type:Journal (On-line/Unpaginated)
Additional Information:article number 021909
Keywords:neural networks, cerebral cortex, membrane potential, synapses, stochastic process
Subjects:Neuroscience > Biophysics
Neuroscience > Computational Neuroscience
Biology > Theoretical Biology
ID Code:2480
Deposited By:Hillenbrand, Dr. Ulrich
Deposited On:29 Sep 2002
Last Modified:11 Mar 2011 08:55

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