Predictability of hand skill and cognitive abilities from craniofacial width in right- and left-handed men and women: relation of skeletal structure to cerebral function

Dayi, Ertunc and Okuyan, Mukadder and Tan, Uner (2002) Predictability of hand skill and cognitive abilities from craniofacial width in right- and left-handed men and women: relation of skeletal structure to cerebral function. [Journal (Paginated)]

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Recently, a family of homeobox genes involved in brain and craniofacial development was identified. In light of this genetic background, we hypothesized that some functional characteristics of human brain (hand skill, cognition) may be linked to some structural characteristics of human skull (e.g. craniofacial width) in humans. Hand preference was assessed by the Oldfield`s Handedness Questionaire. Hand skill was measured by Peg Moving Task. Face width was measured from the anteroposterior cephalograms (X-ray) using right (R) and left (L) zygomatic points. Intelligence “g” was assessed by Cattell`s Culture Fair Intelligence Test; the perceptual-verbal ability was assessed by “Finding A`s Test”; the spatial ability was assessed by the mental rotation task, in right- and left-handed men and women. The percentages of right-, left-, and mixed-faced subjects were close to those found for paw preference in cats. So, Women tended to be more right-faced (R-L > 0) and less left-faced (R-L < 0) than men who were tended to be more left-faced and less right-faced than women. R-L face width inversely correlated with L-R PMT (peg moving time) in left-handers; there was a direct relation between these variables in right-handers. Cattell-IQ linearly increased with R-L face width in left-handers, negatively correlated in right-handed men and women. Verbal ability inversely related to R – L face width in right- and left-handed men, but directly correlated in right-handed women. Number correct on mental rotation task positively linearly correlated with R-L face width in left-handers and right-handed women. It was concluded that the structural-functional coupling revealed in the present work may have its origins in parallel development of the craniofacial skeleton and brain under the influence of homeobox genes.

Item Type:Journal (Paginated)
Keywords:brain, cognition, face, skeleton, genetics, hand skill, hand preference, sex difference, verbal ability, spatial ability
Subjects:Neuroscience > Behavioral Neuroscience
Neuroscience > Neuropsychology
Psychology > Perceptual Cognitive Psychology
ID Code:2198
Deposited By:Tan, Uner
Deposited On:04 May 2002
Last Modified:11 Mar 2011 08:54

References in Article

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Blaschke, R. J., Monaghan, A. P., Schiller, S., Schehinger, B., Rao, E., Padilla-Nash, H.,

Ried, T., & Rappold, G. A. (1998). SHOT, a SHOX-related homeobox gene, is implicated

in craniofacial, brain, heart, and limb development.

Proceedings of National Academy of Sciences, USA, 95, 2406-2411.

Cattell, R. B. (1987). Intelligence: its structure, growth, and action. Advances in Psychology,

35. Stelmach, G. H., & Vroon, P. A. (Eds.). Amsterdam, The Netherlands: Elsevier Science

Publishers B.V.

Cohen, S. R., Corrigan, M. L., Bookstein, F. L., Trotman, C. A., Burdi, A., & Barr, M.

(1995). Log-linear allometry of fetal craniofacial growth in Down`s syndrome. Journal of

Craniofacial Surgery, 6, 184-189.

Dirksen, M. L., Mathers, P., & Jamrich, M. (1993). Expression of a Xenopus Distal-less

homeobox gene involved in forebrain and cranio-facial development. Mechanisms of

Development, 41, 121-128.

Farkas, L. G., Munro, I. R., & Kolar, J. C. (1985). Abnormal measurements and

disproportions in the face of Down`s syndrome patients: preliminary report of an

anthropometric study. Plastic and Reconstructive Surgery, 75, 159-169.

Farkas, L. G., Katic, M. J., Forrest, C. R., & Litsas, L. (2001). Surface anatomy of the face in

Down`s syndrome: linear and angular measurements in the craniofacial regions.

Craniofacial Surgery, 12, 373-379.

Godfrey, L. R., Samonds, K. E., Jungers, W. L., & Sutherland, M. R. (2001). Teeth, Brains,

and Primate Life Histories. American Journal of Physical Anthropology, 114,192-214.

Gouchie, C., & Kimura, D. (1991). The relationship between testosteroen levels and cognitive

ability patterns. Psychoneuroendocrinology, 16, 323-324.

Halpern, D. F., & Tan, U. (2001). Stereotypes and steroids: using a psychobiosocial model to

understand sex differences. Brain and Cognition, 45, 392-414.

Handoll, N. J. R. (1998). The osteopathic management of children with Down`s syndrome.

British Osteopathic Journal, 21, 11-20.

Keles, P., Diyarbakirli, S., Tan, M., & Tan, U. (1997). Facial asymmetry in right- and

left-handed men and women. International Journal of Neuroscience, 91, 147-160.

Kimura, D., & Hampson, E. (1994). Cognitive pattern in men and women is influenced by

fluctuations in sex hormones. Currect directions in Psychological Science, 3, 57-61.

Merlo, G. R., Zerega, B., Paleari, L., Trombino, S., Mantero, S., & Levi, G. (2000). Multiple

functions of DIx genes. International Journal of Developmental Biology, 44, 619-626.

Nasrallah, I., & Golden, J. A. (2001). Brain, eye, and face defects as a result of ectopic

localization of sonic hedgehog protein in the developing rostral neural tube. Teratology,

64, 107-113.

Nopoulos, P., Berg, S., VanDemark, D., Richman, L., Canady, J., & Andreasen, N. C. (2001).

Increased incidence of a midline brain anomaly in patients with nonsyndromic clefts of the

lip and/or palate. Journal of Neuroimaging: Official Journal of the American Society of

Neuroimaging, 11, 418-424.

Pirila-Parkkinen, K., Pirttiniemi, P., Alvesalo, L., Silven, O., Heikkila, J., & Osborne, R.H.

(2001). The relationship of handedness to asymmetry in the occlusal morphology of first

permanent molars. European Journal of Morphology, 39, 81-89.

Rushton, J. P., & Ankney, C. D. (1996). Brain size and cognitive ability: Correlations with

age, sex, social class, and race. Psychonomic Bulletin and Review, 3, 21-36.

Tan, U. (1987). Paw preference in dogs. International Journal of Neuroscience, 32,825-829.

Tan, U. (1988). The distribution of hand preference in normal men and women. International

Journal of Neuroscience, 41, 35-55.

Tan, U. (1989a). Manual proficiency in Cattell`s Intelligence Test in left-handed male and

female subjects. International Journal of Neuroscience, 44, 17-26.

Tan, U. (1989b). Right and left hand skill in left-handers: distribution, learning, and relation

to nonverbal intelligence. International Journal of Neuroscience, 44, 235-249.

Tan, U. (1990a). The left brain determines the degree of left-handedness. International

Journal of Neuroscience, 53, 75-85.

Tan, U. (1990b). Relation of hand skill to spatial reasoning in male and female left-handers

with left- and right-hand writing.International Journal of Neuroscience, 53, 121-133.

Tan, U., & Kutlu, N. (1991). The distribution of paw preference in right-, left-, and

mixed-pawed male and female cats: the role of a female right-shift factor in handedness.

International Journal of Neuroscience, 59, 219-229.

Tan, U., & Kutlu, N. (1992). Right and left hand skill in relation to cerebral lateralization

In right-handed male and female subjects: The prominent role of the right brain in right-

Handedness. International Journal of Neuroscience, 64, 125-138.

Tan, U., Ors, R., Kurkcuoglu, M., & Kutlu, N. (1992a). The lateralization of the grasp reflex

in human newborns. International Journal of Neuroscience, 62, 1-8.

Tan, U., Ors, R., Kurkcuoglu, M., Kutlu, N., & Cankaya, A. (1992b). Lateralization of the

grasp reflex in male and female human newborns. International Journal of Neuroscience,

62, 155-163.

Tan, U., & Tan, M. (1998). Curvelinear correlations between total testosterone levels and

fluid intelligence in men and women. International Journal of Neuroscience, 95, 77-83.

Tan, U., Tan, M., Polat, P., Ceylan, Y., Suma, S., & Okur, A. (1999). Magnetic resonance

imaging brain size/IQ relations in Turkish university students. Intelligence, 27, 83-92.

Tan, U., Yaprak, M., & Kutlu, N. (1990a). Paw preference in cats: distribution and sex

differences. International Journal of Neuroscience, 50, 195-208.

Trainor, P. A., & Krumlauf, R. (2001). Hox genes, neural crest cells and branchial arch

patterning. Current Opinion in Cell Biology, 13, 698-705.

Vandenberg, S. G., & Kuse, A. R. (1978). Mental rotation: a group test of three-dimensional

spatial visualization. Perceptual and Motor Skills, 47, 599-601.

Wilkie, A.O.M., & Morriss-Kay, G. M. (2001). Genetics of craniofacial development and

malformation. Nature Reviews Genetics, 2, 458-468.

Willerman, L., Schultz, R., Rutledge, J. N., & Bigler, E. D. (1992). Hemisphere size

asymmetry predicts relative and nonverbal intelligence differently in the sexes – an MRI

study of structure-function relations. Intelligence, 16, 315-328.


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