Cogprints

Novelty-elicited mismatch negativity in patients with schizophrenia on admission and discharge

Grzella, and Müller, and Oades, and Bender, and Schall, and Zerbin, and Wolstein, and Sartory, (2001) Novelty-elicited mismatch negativity in patients with schizophrenia on admission and discharge. [Journal (Paginated)]

Full text available as:

[img] PDF
977Kb

Abstract

Introduction: MMN, an electrophysiological measure of auditory working memory, is usually recorded as the difference in the event-related potential (ERP) elicited by a rare deviant and a common standard sound. The amplitude is usually reduced in patients with schizophrenia (refs below). Here we looked at the response in the extreme and most simple case of the deviant being always a novel, different tone on every presentation. We compared the novelty-MMN with clinical symptoms expressed - both measures being made soon after admission and again 2-3 months later just before discharge. Methods: We compared 20 patients (mean age 26y) with a first, second or third episode of schizophrenia on admission with 21 healthy controls (mean age 26y) and were able to repeat the measures with 12 patients at discharge and with 15 controls. An early MMN component (80-140 ms), a later component (140-300 ms) and the P3a were recorded and topography examined after min-max norming from 19 sites. Symptoms were assessed with the positive and negative syndrome scale (PANSS). Results: a) Novelty-elicited MMN was not significantly reduced on admission. b) The early component remained unaltered, but the amplitude of the later component decreased significantly during inpatient treatment. While the decrease appeared significant over the left hemisphere in the raw data, the lateral difference was lost after normalizing the data. c) Improved positive symptom ratings were associated with increases of the early component latency, but decreases of the late component latency. d) P3a at Fz showed an increased latency between sessions in the patients but there were no group differences in amplitude. Conclusions: Our results are partially consistent with two other studies using a conventional MMN that showed a lack of MMN normalization where symptoms improved (Schall et al., 1998; Umbricht et al., 1998) - in the present study MMN deteriorated. While trait features have been attributed to conventional MMN reductions in schizophrenia, our results suggest that if novelty responses are impaired in patients with schizophrenia then the differences may be sensitive to state.

Item Type:Journal (Paginated)
Keywords:EEG, Event-related Potential, ERP, Mismatch negativity, MMN, P3a, Novelty, auditory, amplitude, latency, topography, schizophrenia, state, trait, change-detection, course, treatment, symptoms
Subjects:Neuroscience > Neurophysiology
Neuroscience > Neuropsychiatry
Psychology > Perceptual Cognitive Psychology
Psychology > Psychophysiology
ID Code:2050
Deposited By: OADES, Robert D.
Deposited On:29 Jan 2002
Last Modified:11 Mar 2011 08:54

References in Article

Select the SEEK icon to attempt to find the referenced article. If it does not appear to be in cogprints you will be forwarded to the paracite service. Poorly formated references will probably not work.

1. Näätänen R: The role of attention in auditory information processing as revealed by event-related potentials and other brain measures of cognitive function. Behavioral and Brain Sciences 1990;13:201-88.

2. Paavilainen P, Tiitinen H, Alho K, Näätänen R: Mismatch negativity to slight pitch changes outside strong attentional focus. Biol.Psychol. 1993;37:23-41.

3. Kropotov JD, Näätänen R, Sevostianov AV, Alho K, Reinikainen K, Kropotova OV: Mismatch negativity to auditory stimulus change recorded directly from the human temporal cortex. Psychophysiology 1995;32:418-22.

4. Javitt DC, Steinschneider M, Schroeder CE, Vaughan HGJ, Arezzo JC: Detection of stimulus deviance within primate primary auditory cortex: intracortical mechanisms of mismatch negativity (MMN) generation. Brain Res. 1994;667:192-200.

5. Näätänen R, Lehtokoski A, Lennes M, et al: Language-specific phoneme representations revealed by electric and magnetic brain responses. Nature 1997;385:432-4.

6. Alain C, Woods DL, Ogawa KH: Brain indices of automatic pattern processing. Neuroreport. 1994;6:140-4.

7. Trejo LJ, Ryan-Jones DL, Kramer AF: Attentional modulation of the mismatch negativity elicited by frequency differences between binaurally presented tone bursts. Psychophysiology 1995;32:319-28.

8. Oades RD, Dittmann-Balcar A: Mismatch negativity (MMN) is altered by directing attention. Neuroreport. 1995;6:1187-90.

9. Alain C, Hargrave R, Woods DL: Processing of auditory stimuli during visual attention in patients with schizophrenia. Biol.Psychiatry 1998;44:1151-9.

10. Woldorff MG, Hillyard SA, Gallen CC, Hampson SR, Bloom FE: Magnetoencephalographic recordings demonstrate attentional modulation of mismatch-related neural activity in human auditory cortex. Psychophysiology 1998;35:283-92.

11. Dittmann-Balcar A, Thienel R, Schall U: Attention dependent allocation of auditory processing resources as measured by mismatch negativity. Neuroreport. 1999;10:1-5.

12. Cowan N, Winkler I, Teder W, Näätänen R: Memory prerequisites of mismatch negativity in the auditory event- related potential (ERP). J.Exp.Psychol.Learn.Mem.Cogn. 1993;19:909-21.

13. Shelley AM, Ward PB, Catts SV, Michie PT, Andrews S, McConaghy N: Mismatch negativity: an index of a preattentive processing deficit in schizophrenia. Biol.Psychiatry 1991;30:1059-62.

14. Oades RD: Bases of irrelavant information processing in schizophrenia: room for manoeuvre. Commentary on "The Neuropsychology of Schizophrenia", J.A. Gray et al., The Behavioral and Brain Sciences, 14, 1-84. Behavioral and Brain Sciences 1991;14:38-9.

15. Javitt DC, Doneshka P, Zylberman I, Ritter W, Vaughan HGJ: Impairment of early cortical processing in schizophrenia: an event- related potential confirmation study. Biol.Psychiatry 1993;33:513-9.

16. Javitt DC, Doneshka P, Grochowski S, Ritter W: Impaired mismatch negativity generation reflects widespread dysfunction of working memory in schizophrenia. Arch.Gen.Psychiatry 1995;52:550-8.

17. Catts SV, Shelley AM, Ward PB, et al: Brain potential evidence for an auditory sensory memory deficit in schizophrenia. Am.J.Psychiatry 1995;152:213-9.

18. Shutara Y, Koga Y, Fujita K, Takeuchi H, Mochida M, Takemasa K: An event-related potential study on the impairment of automatic processing of auditory input in schizophrenia. Brain Topogr. 1996;8:285-9.

19. Javitt DC, Grochowski S, Shelley AM, Ritter W: Impaired mismatch negativity (MMN) generation in schizophrenia as a function of stimulus deviance, probability and interstimulus interdeviant interval. Clinical Neurophysiology 1998;108:143-53.

20. Kasai K, Okazawa K, Nakagome K, et al: Mismatch negativity and N2b attenuation as an indicator for dysfunction of the preattentive and controlled processing for deviance detection in schizophrenia: a topographic event-related potential study. Schizophr.Res. 1999;35:141-56.

21. Schall U, Catts SV, Karayanidis F, Ward PB: Auditory event-related potential indices of fronto-temporal information processing in schizophrenia syndromes: Valid outcome prediction of clozapine therapy in a three-year follow-up. International Journal of Neuropsychopharmacology 1999;2:83-93.

22. Oades RD, Dittmann-Balcar A, Zerbin D, Grzella I: Impaired attention-dependent augmentation of MMN in nonparanoid vs paranoid schizophrenic patients: a comparison with obsessive-compulsive disorder and healthy subjects. Biol.Psychiatry 1997;41:1196-210.

23. Alain C, Woods DL, Knight RT: A distributed cortical network for auditory sensory memory in humans. Brain Res. 1998;812:23-37.

24. Salisbury DF, Farrell D, Shenton ME, Fischer IA, Zarate C, McCarley RW: Mismatch negativity is reduced in chronic but not first episode schizophrenia. Biol.Psychiatry 1999;45:25S

25. O'Donnell BF, Hokama H, McCarley RW, et al: Auditory ERPs to non-target stimuli in schizophrenia: relationship to probability, task-demands, and target ERPs. Int.J.Psychophysiol. 1994;17:219-31.

26. Kathmann N, Wagner M, Rendtorff N, Engel RR: Delayed peak latency of the mismatch negativity in schizophrenics and alcoholics. Biol.Psychiatry 1995;37:754-7.

27. Schroeder MM, Ritter W, Vaughan HGJ: The mismatch negativity to novel stimuli reflects cognitive decline. Ann.N.Y.Acad.Sci. 1995;769:399-401:399-401.

28. Alho K, Winkler I, Escera C, et al: Processing of novel sounds and frequency changes in the human auditory cortex: magnetoencephalographic recordings. Psychophysiology 1998;35:211-24.

29. Opitz B, Mecklinger A, Friederici AD, von Cramon DY: The functional neuroanatomy of novelty processing: integrating ERP and fMRI results. Cereb.Cortex. 1999;9:379-91.

30. Escera C, Alho K, Winkler I, Näätänen R: Neural mechanisms of involuntary attention to acoustic novelty and change. J.Cogn.Neurosci. 1998;10:590-604.

31. Knight RT, Nakada T: Cortico-limbic circuits and novelty: a review of EEG and blood flow data. Rev.Neurosci. 1998;9:57-70.

32. Schall U, Catts SV, Chaturvedi S, et al: The effect of clozapine therapy on frontal lobe dysfunction in schizophrenia: neuropsychology and event-related potential measures. International Journal of Neuropsychopharmacology 1998;1:19-29.

33. Umbricht D, Javitt D, Novak G, et al: Effects of clozapine on auditory event-related potentials in schizophrenia. Biol.Psychiatry 1998;44:716-25.

34. Baldeweg T, William JD, Gruzelier JH: Differential changes in frontal and sub-temporal components of mismatch negativity. Int.J.Psychophysiol. 1999;33:143-8.

35. Sussman E, Winkler I, Ritter W, Alho K, Naatanen R: Temporal integration of auditory stimulus deviance as reflected by the mismatch negativity. Neurosci.Lett. 1999;264:161-4.

36. Kay, S. R., Opler, L. A., and Fiszbein, A. Positive and negative syndrome scale (PANSS) manual. 1992. Toronto, Multi-Health Systems. (GENERIC)

Ref Type: Generic

37. Bunney WE, Hamburg DA: Methods of reliable longitudinal observation of behaviour. Arch.Gen.Psychiatry 1963;9:280

38. Chouinard G, Ross-Couinard A, Annable L, Jones BD: The Extrapyramidal Symptom Rating Scale. Canadian Journal of Neurological Science 1980;7:233

39. Guy, W. Assessment Manual for Psychopharmacology. 1976. Rockville, National Institute of Mental Health. (GENERIC)

Ref Type: Pamphlet

40. Davis JM: Dose equivalence of the antipsychotic drugs., in Matthysse SW, Kety SS (eds): Catecholamines and schizophrenia. Oxford, Pergamon Press.; 1975:65-69.

41. Rey MJ, Schulz P, Kosta C, Dick P, Tissot R: Guidelines for the dosage of neuroleptics. I: Chlorpromazine equivalents of orally administered neuroleptics. Int.Clin.Psychopharmacol. 1989;4:95-104.

42. McCarthy G, Wood CC: Scalp distributions of event-related potentials: an ambiguity associated with analysis of variance models. Electroencephalogr.Clin.Neurophysiol. 1985;62:203-8.

43. Näätänen R, Alho K: Mismatch negativity--a unique measure of sensory processing in audition. Int.J.Neurosci. 1995;80:317-37.

44. Kreitschmann-Andermahr I, Rosburg T, Meier T, Volz HP, Nowak H, Sauer H: Impaired sensory processing in male patients with schizophrenia: a magnetoencephalographic study of auditory mismatch detection. Schizophr.Res. 1999;35:121-9.

45. Shelley AM, Silipo G, Javitt DC: Diminished responsiveness of ERPs in schizophrenic subjects to changes in auditory stimulation parameters: implications for theories of cortical dysfunction. Schizophr.Res. 1999;37:65-79.

46. Saigusa T, Tuinstra T, Koshikawa N, Cools AR: High and low responders to novelty: effects of a catecholamine synthesis inhibitor on novelty-induced changes in behavior and release of accumbal dopamine. Neuroscience 1999;88:1153-63.

47. Ritter W, Simson R, Vaughan HGJ, Friedman D: A brain event related to the making of a sensory discrimination. Science 1979;203:1358-61.

48. Sams M, Paavilainen P, Alho K, Naatanen R: Auditory frequency discrimination and event-related potentials. Electroencephalogr.Clin.Neurophysiol. 1985;62:437-48.

49. Novak GP, Ritter W, Vaughan HGJ, Wiznitzer ML: Differentiation of negative event-related potentials in an auditory discrimination task. Electroencephalogr.Clin.Neurophysiol. 1990;75:255-75.

50. Potts GF, Hiramatsu K: High-density recording and topographic analysis of the auditory oddball event-related potential in patients with schizophrenia. Biol.Psychiatry 1998;44:982-9.

51. Oades RD, Zerbin D, Dittmann-Balcar A, Eggers C: Auditory event-related potential (ERP) and difference-wave topography in schizophrenic patients with/without active hallucinations and delusions: a comparison with young obsessive-compulsive disorder (OCD) and healthy subjects. Int.J.Psychophysiol. 1996;22:185-214.

52. Hirayasu Y, Potts GF, O'Donnell BF, et al: Auditory mismatch negativity in schizophrenia: topographic evaluation with a high-density recording montage. Am.J.Psychiatry 1998;155:1281-4.

53. Bender S, Schall U, Wolstein J, Grzella I, Zerbin D, Oades RD: A topographic event-related potential (ERP follow-up study on 'prepulse inhibition' in first and second episode patients with schizophrenia. Psychiatry Res. 1999;90:41-53.

54. Andreasen NC, O'Leary DS, Cizadlo T, et al: Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry. Proc.Natl.Acad.Sci.U.S.A. 1996;93:9985-90.

55. Grillon C, Courchesne E, Ameli R, Geyer MA, Braff DL: Increased distractibility in schizophrenic patients. Electrophysiological and behavioral evidence. Arch.Gen.Psychiatry 1990;47:171-9.

56. Mathalon DH, Ford JM, Pfefferbaum A: Trait and state aspects of P300 amplitude reduction in schizophrenia: a retrospective longitudinal study. Biol.Psychiatry 2000.Mar.1.;47.(5.):434.-49. 2000;47:434-49.

57. Mathalon DH, Ford JM, Rosenbloom M, Pfefferbaum A: P300 reduction and prolongation with illness duration in schizophrenia. Biol.Psychiatry 2000.Mar.1.;47.(5.):413.-27. 2000;47:413-27.

58. Turetsky B, Colbath EA, Gur RE: P300 subcomponent abnormalities in schizophrenia: II. Longitudinal stability and relationship to symptom change. Biol.Psychiatry 1998;43:31-9.

59. Frangou S, Sharma T, Alarcon G, et al: The Maudsley Family Study, II: Endogenous event-related potentials in familial schizophrenia. Schizophr.Res. 1997;23:45-53.

60. O'Donnell BF, Faux SF, McCarley RW, et al: Increased rate of P300 latency prolongation with age in schizophrenia. Electrophysiological evidence for a neurodegenerative process. Arch.Gen.Psychiatry 1995;52:544-9.

61. Olinchey JM, Iragui VJ, Kutas M, Morris S, Jeste DV: Relationship between auditory P300 amplitude and age of onset of schizophrenia in older patients. Psychiatry Res. 1998;79:241-54.

62. Müller BW, Achenbach C, Oades RD, Schall U: Retest stability of mismatch negativity (MMN) and negative difference (Nd) in a four condition novelty oddball task. Psychophysiology 1999;36:S84

Metadata

Repository Staff Only: item control page