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Genetic dissection of mouse exploratory behaviour

Crusio, Wim E. (2001) Genetic dissection of mouse exploratory behaviour. [Journal (Paginated)] (In Press)

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Abstract

A large variety of apparatus and procedures are being employed to measure mouse exploratory behaviour. Definitions of what constitutes exploration also vary widely. The present article reviews two studies, whose results permet a genetic dissection of behaviour displayed in an open-field situation. The results agree that factors representing exploration and stress/fear underly this type of behaviour. Both factors appear to be linked to neuroanatomical variation in the sizes of the hippocampal intra- and infrapyramidal mossy fiber terminal fields. Multivariate analysis of genetic correlations may render inmportant insights into the structure of behaviour and its relations with neuroanatomical and neurophysiological systems.

Item Type:Journal (Paginated)
Keywords:Exploration; Locomotor activity; Quantitative genetics; Genetic correlation; Mouse; Hippocampal mossy fibres
Subjects:Neuroscience > Behavioral Neuroscience
Biology > Animal Behavior
Psychology > Psychobiology
ID Code:1671
Deposited By:Crusio, Wim E
Deposited On:06 Aug 2001
Last Modified:11 Mar 2011 08:54

References in Article

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[1]Alleva, E., Fasolo, A., Lipp, H.P., Nadel, L. and Ricceri, L. (Eds.), NATO ASI Series. Series D, Behavioural and Social Sciences, Vol. 82, Behavioural Brain Research in Naturalistic and Semi-Naturalistic Settings, Kluwer Academic Publishers, Dordrecht, 1995, 466 pp.

[2]Archer, J., Tests for emotionality in rats and mice: a review, Animal Behaviour, 21 (1973) 205-235.

[3]Barber, R.P., Vaughn, J.E., Wimer, R.E. and Wimer, C.C., Genetically-associated variations in the distribution of dentate granule cell synapses upon the pyramidal cell dendrites in mouse hippocampus, Journal of Comparative Neurology, 156 (1974) 417-34.

[4]Barnett, S.A. and Cowan, P.E., Activity, exploration, curiosity and fear: An ethological study, Interdisciplinary Science Reviews, 1 (1976) 43-62.

[5]Blodgett, H.C., The effect of the introduction of reward upon the maze performance of rats, University of California Publications in Psychology, 4 (1929) 113-134.

[6]Broadhurst, P.L. and Jinks, J.L., What genetical architecture can tell us about the natural selection of behavioural traits. In J.H.F. van Abeelen (Ed.), The Genetics of Behaviour, North-Holland, Amsterdam, 1974, pp. 43-63.

[7]Crusio, W.E., Quantitative genetics. In D. Goldowitz, D. Wahlsten and R.E. Wimer (Eds.), Techniques for the Genetic Analysis of Brain and Behavior: Focus on the Mouse, Vol. 8, Elsevier, Amsterdam, 1992, pp. 231-250.

[8]Crusio, W.E., Bi- and multivariate analyses of diallel crosses: a tool for the genetic dissection of neurobehavioral phenotypes, Behavior Genetics, 23 (1993) 59-67.

[9]Crusio, W.E., An introduction to quantitative genetics. In B.C. Jones and P. Mormède (Eds.), Neurobehavioral Genetics: Methods and Applications, CRC Press, Boca Raton, Fl., 2000, pp. 13-30.

[10]Crusio, W.E., Genthner-Grimm, G. and Schwegler, H., A quantitative-genetic analysis of hippocampal variation in the mouse, Journal of Neurogenetics, 3 (1986) 203-214.

[11]Crusio, W.E. and Schwegler, H., Hippocampal mossy fiber distribution covaries with open-field habituation in the mouse, Behavioural Brain Research, 26 (1987) 153-158.

[12]Crusio, W.E., Schwegler, H. and Brust, I., Covariations between hippocampal mossy fibres and working and reference memory in spatial and non-spatial radial maze tasks in mice, European Journal of Neuroscience, 5 (1993) 1413-1420.

[13]Crusio, W.E., Schwegler, H., Brust, I. and van Abeelen, J.H.F., Genetic selection for novelty-induced rearing behavior in mice produces changes in hippocampal mossy fiber distributions, Journal of Neurogenetics, 5 (1989) 87-93.

[14]Crusio, W.E., Schwegler, H. and Lipp, H.-P., Radial-maze performance and structural variation of the hippocampus in mice: a correlation with mossy fibre distribution, Brain Research, 425 (1987) 182-185.

[15]Crusio, W.E., Schwegler, H. and van Abeelen, J.H.F., Behavioral responses to novelty and structural variation of the hippocampus in mice. I. Quantitative-genetic analysis of behavior in the open-field, Behavioural Brain Research, 32 (1989) 75-80.

[16]Crusio, W.E., Schwegler, H. and van Abeelen, J.H.F., Behavioral responses to novelty and structural variation of the hippocampus in mice. II. Multivariate genetic analysis, Behavioural Brain Research, 32 (1989) 81-88.

[17]Crusio, W.E., Schwegler, H. and van Abeelen, J.H.F., Behavioural and neuroanatomical divergence between two sublines of C57BL/6J inbred mice, Behavioural Brain Research, 42 (1991) 93-97.

[18]Crusio, W.E. and van Abeelen, J.H., The genetic architecture of behavioural responses to novelty in mice, Heredity, 56 (1986) 55-63.

[19]Flint, J., Corley, R., DeFries, J.C., Fulker, D.W., Gray, J.A., Miller, S. and Collins, A.C., A simple genetic basis for a complex psychological trait in laboratory mice, Science, 269 (1995) 1432-1435.

[20]Foshee, D.P., Vierck, C.J., Meier, G.W. and Federspiel, C., Simultaneous measure of general activity and exploratory behavior, Perceptual and Motot Skills, 20 (1965) 445-451.

[21]Gerlai, R., Crusio, W.E. and Csanyi, V., Inheritance of species-specific behaviors in the paradise fish (Macropodus opercularis): a diallel study, Behavior Genetics, 20 (1990) 487-98.

[22]Gray, J.A. and McNaughton, N., Comparison between the behavioural effects of septal and hippocampal lesions: a review, Neuroscience and Biobehavioral Reviews, 7 (1983) 119-188.

[23]Hayman, B.I., The theory and analysis of diallel crosses, Genetics, 39 (1954) 789-809.

[24]Henderson, N.D., Predicting relationships between psychological constructs and genetic characters: an analysis of changing genetic influences on activity in mice, Behavior Genetics, 16 (1986) 201-220.

[25]Jamot, L., Bertholet, J.Y. and Crusio, W.E., Neuroanatomical divergence between two substrains of C57BL/6J inbred mice entails differential radial-maze learning, Brain Research, 644 (1994) 352-356.

[26]Kelley, A.E., Cador, M. and Stinus, L., Exploration and its measurement. A psychopharmacological perspective. In A.B. Boulton, G.B. Baker and A.J. Greenshaw (Eds.), Neuromethods, Volume 13: Psychopharmacology, Humana Press, Clifton, 1989, pp. 95-144.

[27]Moser, E.I., Moser, M.B. and Andersen, P., Potentiation of dentate synapses initiated by exploratory learning in rats: dissociation from brain temperature, motor activity, and arousal, Learning and Memory, 1 (1994) 55-73.

[28]O'Keefe, J. and Nadel, L., The Hippocampus as a Cognitive Map, Clarendon Press, Oxford, 1978, 570 pp.

[29]Renner, M.J., Learning during exploration: The role of behavioral topography during exploration in determining subsequent adaptive behavior, International Journal of Comparative Psychology, 2 (1988) 43-56.

[30]Roullet, P. and Lassalle, J.M., Genetic variation, hippocampal mossy fibres distribution, novelty reactions and spatial representation in mice, Behavioural Brain Research, 41 (1990) 61-70.

[31]SAS Institute Inc, SAS/STAT Guide for Personal Computers, Version 6 Edition, Sas Institute Inc., Cary, NC, 1987, 1031 pp.

[32]Schmajuk, N.A., Psychological theories of hippocampal function, Physiological Psychology, 12 (1984) 166-183.

[33]Schwegler, H. and Crusio, W.E., Correlations between radial-maze learning and structural variations of septum and hippocampus in rodents, Behavioural Brain Research, 67 (1995) 29-41.

[34]Takahashi, J.S., Pinto, L.H. and Vitaterna, M.H., Forward and reverse genetic approaches to behavior in the mouse, Science, 264 (1994) 1724-1733.

[35]Talbot, C.J., Nicod, A., Cherny, S.S., Fulker, D.W., Collins, A.C. and Flint, J., High-resolution mapping of quantitative trait loci in outbred mice, Nature Genetics, 21 (1999) 305-308.

[36]van Abeelen, J.H.F., Mouse mutants studied by means of ethological methods. I. Ethogram, Genetica, 34 (1963) 79-94.

[37]van Abeelen, J.H.F., Genetics of rearing behavior in mice, Behavior Genetics, 1 (1970) 71-76.

[38]van Abeelen, J.H.F., Genotype and the cholinergic control of exploratory behaviour in mice. In J.H.F. van Abeelen (Ed.), The Genetics of Behaviour, North-Holland, Amsterdam, 1974, pp. 347-374.

[39]van Abeelen, J.H.F., Genetic control of hippocampal cholinergic and dynorphinergic mechanisms regulating novelty-induced exploratory behavior in house mice, Experientia, 45 (1989) 839-845.

[40]Wahlsten, D., Lassalle, J.-M. and Bulman-Fleming, B., Hybrid vigour and maternal environment in mice. III. Hippocampal mossy fibres and behaviour, Behavioural Processes, 23 (1991) 47-57.

[41]Walsh, R.N. and Cummins, R.A., The open-field test: A critical review, Psychological Bulletin, 83 (1976) 482-504.

[42]Weischer, M.L., Eine einfache Versuchsanordnung zur quantitativen Beurteilung von Motilität und Neugierverhalten bei Mäusen, Psychopharmacology, 50 (1976) 275-279.

[43]Whimbey, A.E. and Denenberg, V.H., Two independent behavioral dimensions in open-field performance, Journal of Comparative and Physiological Psychology, 63 (1967) 500-504.

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